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抗炎蛋白 TNFα 刺激基因-6（TSG-6）可减少小鼠脑损伤后的炎症反应。

Anti-inflammatory protein TNFα-stimulated gene-6 (TSG-6) reduces inflammatory response after brain injury in mice.

机构信息

College of Optometry, University of Houston, 4901 Calhoun Road, Houston, TX, 77204-2020, USA.

Department of Bioengineering, Rice University, Houston, TX, 77030, USA.

出版信息

BMC Immunol. 2021 Aug 4;22(1):52. doi: 10.1186/s12865-021-00443-7.

DOI:10.1186/s12865-021-00443-7
PMID:34348643
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8336266/
Abstract

BACKGROUND

Current research suggests that the glial scar surrounding penetrating brain injuries is instrumental in preserving the surrounding uninjured tissue by limiting the inflammatory response to the injury site. We recently showed that tumor necrosis factor (TNF)-stimulated gene-6 (TSG-6), a well-established anti-inflammatory molecule, is present within the glial scar. In the present study we investigated the role of TSG-6 within the glial scar using TSG-6 null and littermate control mice subjected to penetrating brain injuries.

RESULTS

Our findings show that mice lacking TSG-6 present a more severe inflammatory response after injury, which was correlated with an enlarged area of astrogliosis beyond the injury site.

CONCLUSION

Our data provides evidence that TSG-6 has an anti-inflammatory role within the glial scar.

摘要

背景

目前的研究表明，穿透性脑损伤周围的神经胶质瘢痕通过限制损伤部位的炎症反应，对周围未受伤的组织起到保护作用。我们最近发现，肿瘤坏死因子（TNF）刺激基因-6（TSG-6）是一种成熟的抗炎分子，存在于神经胶质瘢痕中。在本研究中，我们使用 TSG-6 缺失和同窝对照小鼠进行穿透性脑损伤，研究了 TSG-6 在神经胶质瘢痕中的作用。

结果

我们的研究结果表明，缺乏 TSG-6 的小鼠在损伤后表现出更严重的炎症反应，这与损伤部位以外的星形胶质细胞增生面积增大有关。

结论

我们的数据提供了证据，表明 TSG-6 在神经胶质瘢痕中具有抗炎作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4c1c/8336266/d66d0c1efd7b/12865_2021_443_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4c1c/8336266/7bcf37e4951f/12865_2021_443_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4c1c/8336266/7f93e67a6911/12865_2021_443_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4c1c/8336266/65da6d31da8f/12865_2021_443_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4c1c/8336266/3d657fb13307/12865_2021_443_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4c1c/8336266/d66d0c1efd7b/12865_2021_443_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4c1c/8336266/7bcf37e4951f/12865_2021_443_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4c1c/8336266/7f93e67a6911/12865_2021_443_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4c1c/8336266/65da6d31da8f/12865_2021_443_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4c1c/8336266/3d657fb13307/12865_2021_443_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4c1c/8336266/d66d0c1efd7b/12865_2021_443_Fig5_HTML.jpg

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2
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Front Pharmacol. 2019 Sep 27;10:1114. doi: 10.3389/fphar.2019.01114. eCollection 2019.
3
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4
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Neurosci Bull. 2025 Mar;41(3):421-433. doi: 10.1007/s12264-024-01326-8. Epub 2024 Dec 17.
5
Brain Ischemic Tolerance Triggered by Preconditioning Involves Modulation of Tumor Necrosis Factor-α-Stimulated Gene 6 (TSG-6) in Mice Subjected to Transient Middle Cerebral Artery Occlusion.预处理触发的脑缺血耐受性涉及对短暂大脑中动脉闭塞小鼠中肿瘤坏死因子-α刺激基因6（TSG-6）的调节。
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6
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10
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4
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5
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6
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7
Long-Term Cognitive and Neuropsychiatric Consequences of Repetitive Concussion and Head-Impact Exposure.重复性脑震荡和头部撞击暴露的长期认知和神经精神后果。
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8
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9
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Matrix Biol. 2017 Jul;60-61:38-56. doi: 10.1016/j.matbio.2016.12.001. Epub 2016 Dec 6.
10
Traumatic brain injuries.颅脑损伤。
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