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黄热病病毒的系统动力学研究为其在非洲的地理传播提供了新见解。

Phylodynamic Investigation of Yellow Fever Virus Sheds New Insight on Geographic Dispersal Across Africa.

作者信息

Motayo Babatunde Olanrewaju, Opayele Adewale, Akinduti Paul Akiniyi, Faneye Adedayo Omotayo, Omoregie Isibor Patrick

机构信息

Department of Medical Microbiology, Federal Medical Centre, Abeokuta, Nigeria.

Department of Virology, College of Medicine, University of Ibadan, Ibadan, Nigeria.

出版信息

Evol Bioinform Online. 2024 Dec 17;20:11769343241309247. doi: 10.1177/11769343241309247. eCollection 2024.

DOI:10.1177/11769343241309247
PMID:39691473
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11650462/
Abstract

BACKGROUND

Molecular epidemiology has shown the presence of four genotypes circulating across Africa, a paucity of data exists regarding phylogeography of the African Yellow fever (YF) genotypes. The need to fill this gap with spatiotemporal data from continuous YF outbreaks in Africa conceptualized this study; which aims to investigate the most recent transmission events and directional spread of yellow fever virus (YFV) using updated genomic sequence data.

METHODS

Yellow fever sequence data was utilized along with epidemiologic data from outbreaks in Africa, to analyze the case/fatality distribution and genetic diversity. Phylodynamic and phylogeographic were utilized to investigate ancestral history, virus population dynamics, and geographic dispersal of yellow fever across Africa.

RESULTS

There was a sharp increase in laboratory confirmed cases after year 2015, with Nigeria and the Democratic Republic of Congo having the highest numbers of cases. Phylogeny of the YF genotypes followed a previously reported pattern with distinct geographic clustering. Historical dispersal of YFV was discovered to have occurred from West into Central/East Africa, with recent introductions occurring in West Africa.

CONCLUSIONS

We have shown the continuous circulation of YF in Africa, with distinct genotype distributions within the west and central African sub-regions. We have also shown the potential contribution of African genotypes, in the historical dispersal of yellow fever. We advocate for expanded and integrated molecular surveillance of YFV and other Arboviruses in Africa.

摘要

背景

分子流行病学研究表明，非洲存在四种传播的基因型，但关于非洲黄热病毒（YF）基因型的系统地理学数据匮乏。本研究旨在利用最新的基因组序列数据，填补非洲黄热病持续爆发的时空数据空白，以调查黄热病毒（YFV）最近的传播事件和传播方向。

方法

利用黄热病序列数据以及非洲疫情的流行病学数据，分析病例/死亡分布和遗传多样性。利用系统动力学和系统地理学方法，研究黄热病在非洲的祖先历史、病毒种群动态和地理扩散情况。

结果

2015年后实验室确诊病例急剧增加，尼日利亚和刚果民主共和国的病例数最多。黄热病毒基因型的系统发育遵循先前报道的模式，具有明显的地理聚类。发现黄热病毒的历史传播是从西非传入中非/东非，最近在西非有新的引入。

结论

我们已经证明黄热病在非洲持续传播，在西非和中非次区域内有不同的基因型分布。我们还展示了非洲基因型在黄热病历史传播中的潜在作用。我们主张在非洲扩大和整合对黄热病毒和其他虫媒病毒的分子监测。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7dbe/11650462/00edd0f09875/10.1177_11769343241309247-fig5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7dbe/11650462/ba045d5b322a/10.1177_11769343241309247-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7dbe/11650462/1e4c43c8f67c/10.1177_11769343241309247-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7dbe/11650462/f21478dab3f5/10.1177_11769343241309247-fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7dbe/11650462/747c3b8f74fe/10.1177_11769343241309247-fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7dbe/11650462/00edd0f09875/10.1177_11769343241309247-fig5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7dbe/11650462/ba045d5b322a/10.1177_11769343241309247-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7dbe/11650462/1e4c43c8f67c/10.1177_11769343241309247-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7dbe/11650462/f21478dab3f5/10.1177_11769343241309247-fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7dbe/11650462/747c3b8f74fe/10.1177_11769343241309247-fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7dbe/11650462/00edd0f09875/10.1177_11769343241309247-fig5.jpg

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