Farrell M A, Kaufmann J C, Gilbert J J, Noseworthy J H, Armstrong H A, Ebers G C
Neurology. 1985 Feb;35(2):212-8. doi: 10.1212/wnl.35.2.212.
Although oligoclonal banding is a characteristic feature of MS spinal fluid, some patients do not show this abnormality. Four of 18 consecutive patients with autopsy-proven MS had no oligoclonal bands (OB) in CSF during life or at postmortem. Patients with OB had numerous plasma cells in meninges and plaques (confirmed in sections stained for cytoplasmic immunoglobulin). The four patients without bands had few or no identifiable plasma cells. Therefore, lack of OB correlates with both inactivity of plaques and absence of plasma cells in plaques or meninges. This is another form of heterogeneity in MS.
虽然寡克隆带是多发性硬化症脑脊液的一个特征性表现，但一些患者并未显示出这种异常。在18例经尸检证实为多发性硬化症的连续患者中，有4例在生前或死后脑脊液中均无寡克隆带（OB）。有OB的患者在脑膜和斑块中有大量浆细胞（在细胞质免疫球蛋白染色切片中得到证实）。4例无带的患者几乎没有或没有可识别的浆细胞。因此，缺乏OB与斑块不活跃以及斑块或脑膜中浆细胞的缺失相关。这是多发性硬化症异质性的另一种形式。
