Thompson E J, Kaufmann P, Shortman R C, Rudge P, McDonald W I
Br Med J. 1979 Jan 6;1(6155):16-7. doi: 10.1136/bmj.1.6155.16.
A new modification of polyacrylamide gel electrophoresis (PAGE) was applied to cerebrospinal fluid proteins from patients with multiple sclerosis (MS). The same spinal fluids were also examined by a cytological technique. Over 90% of patients with clinically definite or early probable or latent MS showed abnormal PAGE patterns in the form of oligoclonal gammaglobulin bands. Reactive (atypical, large) lymphocytes or typical plasma cells were found in some patients. In all such cases an oligoclonal pattern was present. The findings of oligoclonal bands provides valuable supporting evidence for the diagnosis of MS in the less definite clinical categories.
一种聚丙烯酰胺凝胶电泳（PAGE）的新改良方法应用于多发性硬化症（MS）患者的脑脊液蛋白检测。同样的脑脊液样本也采用细胞学技术进行了检查。超过90%临床确诊或早期可能或潜在的MS患者显示出异常的PAGE图谱，表现为寡克隆γ球蛋白带。部分患者发现有反应性（非典型、大的）淋巴细胞或典型浆细胞。在所有这些病例中均存在寡克隆图谱。寡克隆带的发现为临床诊断不明确的MS患者提供了有价值的辅助诊断依据。
