Yang Xin, Ding Shengjie, Guo Jinlu, Peng Shuang, Duan Zhiqing, Liu Shi
Department of Gastroenterology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China .
Clin Transl Gastroenterol. 2025 Feb 1;16(2):e00801. doi: 10.14309/ctg.0000000000000801.
Few studies have investigated the association between Life's Essential 8 (LE8) and abnormal bowel health. We aimed to investigate the relationship between LE8 and diarrhea and constipation in the adult population of the United States.
This cross-sectional study, based on population data, used information from the National Health and Nutrition Examination Survey conducted between 2005 and 2010. Diarrhea and constipation were classified based on Bristol Stool Form Scale and stool frequency. LE8 score is composed of 4 health behaviors (diet, physical activity, nicotine exposure, and sleep health) and 4 health factors (body mass index, blood lipids, blood glucose, and blood pressure) and is classified into low (0-49), moderate (50-79), and high (80-100) cardiovascular health groups. Weighted logistic regression and restricted cubic splines were used to analyze the relationship between the LE8 score and abnormal bowel health.
The study comprised 12,369 participants aged 20 years or older, among whom 1,279 (9.7%) had constipation and 1,097 (7.6%) had diarrhea. After adjusting for potential confounders, we observed negative associations between LE8 scores and diarrhea (odds ratio: 0.60, 95% confidence interval: 0.39-0.93), whereas the association between LE8 scores and constipation was not statistically significant (odds ratio: 0.82, 95% confidence interval: 0.59-1.13). In addition, health behavior scores and health factor scores were associated with constipation.
Higher LE8 levels are associated with a lower incidence of diarrhea, but not constipation.
很少有研究调查生命基本八项（LE8）与肠道健康异常之间的关联。我们旨在研究美国成年人群中LE8与腹泻和便秘之间的关系。
这项基于人群数据的横断面研究使用了2005年至2010年期间进行的美国国家健康和营养检查调查的信息。腹泻和便秘根据布里斯托大便分类法和大便频率进行分类。LE8评分由4种健康行为（饮食、体育活动、尼古丁暴露和睡眠健康）和4种健康因素（体重指数、血脂、血糖和血压）组成，并分为低（0 - 49）、中（50 - 79）和高（80 - 100）心血管健康组。采用加权逻辑回归和受限立方样条分析LE8评分与肠道健康异常之间的关系。
该研究包括12369名20岁及以上的参与者，其中1279人（9.7%）患有便秘，1097人（7.6%）患有腹泻。在调整潜在混杂因素后，我们观察到LE8评分与腹泻之间存在负相关（优势比：0.60，95%置信区间：0.39 - 0.93），而LE8评分与便秘之间的关联无统计学意义（优势比：0.82，95%置信区间：0.59 - 1.13）。此外，健康行为评分和健康因素评分与便秘有关。
较高的LE8水平与较低的腹泻发病率相关，但与便秘无关。
