Leech R W, Kohnen P
Am J Pathol. 1974 Dec;77(3):465-75.
The pathogenesis of intraventricular hemorrhage in the newborn includes that of subependymal hemorrhage (SEH), the single most common pathologic alteration seen in the brains of 417 consecutively autopsied infants. A clearly recognizable relationship of SEH to gestational age and clinical status exists in that all SEH occur in premature infants under 2500 g birthweight (although only 56% of all premature infants have SEH) and 95% of SEH occur in infants with the respiratory distress syndrome (although only 60% of infants with the respiratory distress syndrome have SEH). The pathogenesis appears to involve a combination of hypoxia, metabolic acidosis, venous stasis and rupture of the thin-walled veins so prominent in the germinal matrix.
新生儿脑室内出血的发病机制包括室管膜下出血（SEH），这是417例连续尸检婴儿大脑中最常见的单一病理改变。SEH与胎龄和临床状况之间存在明显可辨的关系，即所有SEH均发生于出生体重低于2500g的早产儿（尽管所有早产儿中只有56%发生SEH），95%的SEH发生于患有呼吸窘迫综合征的婴儿（尽管患有呼吸窘迫综合征的婴儿中只有60%发生SEH）。发病机制似乎涉及缺氧、代谢性酸中毒、静脉淤滞以及生发基质中薄壁静脉破裂等多种因素。
