Xiao Yi, Zhao Wenting, Zhao Qiuchan, Pang Kangfeng, Gao Qiaoping, Yang Xiaoqu, Chen Huadi, Xu Hao
Department of Hepatobiliary Surgery, Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong Province, People's Republic of China.
Development Planning Department, Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong Province, People's Republic of China.
BMC Gastroenterol. 2024 Dec 18;24(1):453. doi: 10.1186/s12876-024-03545-9.
Gallstones are a prevalent health issue, with established risk factors such as diet body mass index (BMI) and physical activity. However, the role of Life's Essential 8 (LE8), a composite measure of health behaviors and biological markers, in predicting gallstone risk remains unclear. This study aims to examine the association between LE8 scores and gallstone prevalence in a U.S. adult population.
A cross-sectional analysis was conducted on 2836 adults. LE8 scores were categorized into tertiles, and multivariable logistic regression models assessed the relationship between LE8 and gallstones, with additional nonlinear assessment using restricted cubic spline analysis.
Gallstones prevalence was 10.37%, decreasing with higher LE8 scores. The multivariable analysis showed participants in higher LE8 tertiles had significantly lower gallstone risks compared to the lowest tertile. The spline analysis confirmed a significant nonlinear inverse association between LE8 and gallstone risk.
Higher LE8 scores correlate with a lower prevalence of gallstones, suggesting the potential of LE8 as a predictor of gallstone risk. This emphasizes the value of promoting LE8 components in public health initiatives to reduce gallstone prevalence and medical burden.
胆结石是一个普遍存在的健康问题，存在诸如饮食、体重指数（BMI）和身体活动等既定风险因素。然而，生命必需的八项指标（LE8）作为一种综合衡量健康行为和生物学标志物的指标，在预测胆结石风险方面的作用仍不明确。本研究旨在探讨美国成年人群中LE8评分与胆结石患病率之间的关联。
对2836名成年人进行了横断面分析。将LE8评分分为三分位数，多变量逻辑回归模型评估LE8与胆结石之间的关系，并使用受限立方样条分析进行额外的非线性评估。
胆结石患病率为10.37%，随LE8评分升高而降低。多变量分析显示，与最低三分位数相比，LE8三分位数较高的参与者患胆结石的风险显著较低。样条分析证实LE8与胆结石风险之间存在显著的非线性负相关。
较高的LE8评分与较低的胆结石患病率相关，表明LE8作为胆结石风险预测指标的潜力。这强调了在公共卫生倡议中推广LE8各组成部分以降低胆结石患病率和医疗负担的价值。
