Mousavi Tahoora, Shokoohy Fatemeh, Moosazadeh Mahmood
Molecular and Cell Biology Research Center, Hemoglobinopathy Institute, Mazandaran University of Medical Sciences, Sari, Iran.
Non-communicable Diseases Institute, Molecular and Cellular Biology Research Center, Mazandaran University of Medical Sciences, Sari, Iran.
BMC Oral Health. 2024 Dec 18;24(1):1490. doi: 10.1186/s12903-024-05330-2.
Oral cancer (OC) is the most common malignant tumor of the head and neck (HN) and ranks 16th among the most frequently diagnosed cancers worldwide. A systematic review and meta-analysis aimed to provide an evidence-based analysis of the relationship between polyomaviruses and oral cancer.
The global online databases was used to identify relevant studies published between January 2000 and September 2024. The quality of each article was assessed using the Newcastle-Ottawa Scale (NOS) checklist. Data analysis was performed using STATA Ver. 11 software, and the standard error was calculated using the binomial distribution formula. The heterogeneity of the study results was assessed using the I-square and Q index, while publication bias was examined using the Begg's test. In addition, a random effects model was used to determine the risk difference (RD), and a forest plot diagram was used to present the results with 95% confidence intervals. The Trim and Fill test was applied to estimate publication bias, and sensitivity analysis was performed to assess the influence of individual studies on the overall estimate.
Of the nine studies, the relationship between BK virus (BKV) and the Merkel cell polyomavirus (MCV) and oral cancer was investigated. In five primary studies, and by combining the results of these studies, the risk of oral cancer in MCV and BKV-positive individuals was significantly higher than in the negative groups by 13% (RD: 0.13, 95% CI: 0.00, 0.26) and 2% (RD: 0.02, 95% CI: -0.03, 0.07), respectively. In addition, the association between JC virus (JCV) and oral cancer was investigated in six primary studies. By combining the results of these studies, the risk of oral cancer in JCV-positive individuals was 1% higher than that in JCV-negative individuals (RD: 0.01, 95% CI: -0.02, 0.06).
This meta-analysis showed that there was a significant association between MCV and oral cancer, and the risk of oral cancer in MCV- positive individuals was 13% higher than that in MCV- negative individuals. More preliminary studies are needed on the association between BKV and JCV and the risk of oral cancer.
口腔癌（OC）是头颈部（HN）最常见的恶性肿瘤，在全球最常诊断出的癌症中排名第16位。一项系统评价和荟萃分析旨在对多瘤病毒与口腔癌之间的关系进行循证分析。
使用全球在线数据库来识别2000年1月至2024年9月期间发表的相关研究。使用纽卡斯尔-渥太华量表（NOS）清单评估每篇文章的质量。使用STATA Ver. 11软件进行数据分析，并使用二项分布公式计算标准误差。使用I²和Q指数评估研究结果的异质性，同时使用Begg检验检查发表偏倚。此外，使用随机效应模型确定风险差异（RD），并使用森林图展示结果及其95%置信区间。应用Trim和Fill检验估计发表偏倚，并进行敏感性分析以评估个别研究对总体估计的影响。
在九项研究中，调查了BK病毒（BKV）、默克尔细胞多瘤病毒（MCV）与口腔癌之间的关系。在五项初步研究中，通过合并这些研究的结果，MCV和BKV阳性个体患口腔癌的风险分别比阴性组显著高13%（RD：0.13，95%CI：0.00，0.26）和2%（RD：0.02，95%CI：-0.03，0.07）。此外，在六项初步研究中调查了JC病毒（JCV）与口腔癌之间的关联。通过合并这些研究的结果，JCV阳性个体患口腔癌的风险比JCV阴性个体高1%（RD：0.01，95%CI：-0.02，0.06）。
这项荟萃分析表明，MCV与口腔癌之间存在显著关联，MCV阳性个体患口腔癌的风险比MCV阴性个体高13%。需要对BKV和JCV与口腔癌风险之间的关联进行更多的初步研究。
