不稳定型心绞痛患者血清幽门螺杆菌抗体细胞毒素相关基因A水平的临床意义
Clinical significance of serum Helicobacter pylori antibody cytotoxin-associated gene A levels in patients with unstable angina.
作者信息
Jia Haizhen, Fan Huajun, Zhao Jinhe, Peng Jun, Pan Yunhong, Peng Hongyan
机构信息
Cardiovascular Department, Tianyou Hospital Affiliated to Wuhan University of Science and Technology, Wuhan, 430064, Hubei, People's Republic of China.
Department of Plastic Surgery, Renmin Hospital of Wuhan University, Wuhan, 430060, Hubei, People's Republic of China.
出版信息
Eur J Med Res. 2024 Dec 18;29(1):584. doi: 10.1186/s40001-024-02208-5.
OBJECTIVES
We investigated the clinical significance of serum Helicobacter pylori cytotoxin-associated gene A (CagA) antibody levels in 768 patients with unstable angina (UA).
METHODS
Serum CagA levels were measured using ELISA. Demographic data, serum biomarkers, and SYNTAX scores were collected. Patients were followed up for 1 year for major adverse cardiac events (MACE).
RESULTS
CagA-positive UA patients had higher total cholesterol and hsCRP levels, and SYNTAX scores. CagA levels correlated positively with TC, hsCRP, and SYNTAX scores. Kaplan-Meier analysis showed shorter MACE-free survival in CagA-positive UA patients. CagA levels predicted MACE occurrence within 1 year, along with SYNTAX scores.
CONCLUSIONS
Serum H. pylori CagA antibody positivity is associated with worse prognosis in UA patients. CagA levels correlate with lipid metabolism and inflammatory markers.
目的
我们研究了768例不稳定型心绞痛（UA）患者血清幽门螺杆菌细胞毒素相关基因A（CagA）抗体水平的临床意义。
方法
采用酶联免疫吸附测定法（ELISA）检测血清CagA水平。收集人口统计学数据、血清生物标志物和SYNTAX评分。对患者进行1年的随访，观察主要不良心脏事件（MACE）。
结果
CagA阳性的UA患者总胆固醇、超敏C反应蛋白（hsCRP）水平及SYNTAX评分更高。CagA水平与总胆固醇、hsCRP及SYNTAX评分呈正相关。Kaplan-Meier分析显示，CagA阳性的UA患者无MACE生存时间更短。CagA水平与SYNTAX评分一起可预测1年内MACE的发生。
结论
血清幽门螺杆菌CagA抗体阳性与UA患者预后较差有关。CagA水平与脂质代谢及炎症标志物相关。
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