Zhang Dong-Hong, Yuan Chen, Wang Bei-Bei, Dong Xin-Jiang, Lv Shu-Ping, Li Fei-Hong, Hou Zhen-Xiu, Liu Xiao-Li, Chen Kang
Department of Infection Disease, Shanghai Fifth People's Hospital, Shanghai, China.
Department of Emergency, Shanghai Fengxian District Central Hospital, Shanghai Jiao Tong University Affiliated Sixth People's Hospital South Campus, Shanghai, China.
Front Cardiovasc Med. 2022 Jul 15;9:823885. doi: 10.3389/fcvm.2022.823885. eCollection 2022.
Cardiac syndrome X (CSX) is a condition with normal coronary angiography but angina pectoris. Chronic inflammation caused by () infection may play a pathogenic role in CSX. Therefore, we conducted a meta-analysis to explore the relationship between infection and risk of CSX.
A systematic search in the Web of Science, Medline, Embase and Chinese databases (CNKI and Wanfang) was conducted up to October 2021. Articles on the association between infection and the risk of CSX were included and were analyzed by R software (version 4.1.0).
Ten case-control studies involving 703 CSX patients and 731 healthy controls were included. infection was associated with an increased risk of CSX (OR: 8.29, 95% CI: 4.64-14.82). We also found a significant association in those 25-40 years of age (OR: 1.34, 95% CI: 1.04-1.72), those 40-50 years of age (OR: 11.27, 95% CI: 4.29-29.61), those over 50 years of age (OR: 7.18, 95% CI: 3.59-14.36), those in developing countries [Iran (OR: 12.99, 95% CI: 8.61-19.60) and China (OR: 5.14, 95% CI: 3.09-8.56)]. However, this association was not apparent in a developed country [Italy (OR: 0.93, 95% CI: 0.37-2.33)].
Our study suggested a possible association between infection and the risk of CSX. Its pathogenicity is stronger in middle-aged individuals and some developing countries. However, more studies are needed to further investigate whether early eradication of can reduce the incidence rate of CSX, especially in middle-aged individuals and some developing countries.
心脏X综合征（CSX）是一种冠状动脉造影正常但有胸痛症状的疾病。由（）感染引起的慢性炎症可能在CSX中起致病作用。因此，我们进行了一项荟萃分析，以探讨（）感染与CSX风险之间的关系。
截至2021年10月，在科学网、医学索引、荷兰医学文摘和中文数据库（中国知网和万方）中进行了系统检索。纳入了关于（）感染与CSX风险之间关联的文章，并使用R软件（版本4.1.0）进行分析。
纳入了10项病例对照研究，涉及703例CSX患者和731例健康对照。（）感染与CSX风险增加相关（比值比：8.29，95%置信区间：4.64 - 14.82）。我们还发现在25至40岁人群（比值比：1.34，95%置信区间：1.04 - 1.72）、40至50岁人群（比值比：11.27，95%置信区间：4.29 - 29.61）、50岁以上人群（比值比：7.18，95%置信区间：3.59 - 14.36）、发展中国家[伊朗（比值比：12.99，95%置信区间：8.61 - 19.60）和中国（比值比：5.14，95%置信区间：3.09 - 8.56）]中存在显著关联。然而，在发达国家[意大利（比值比：0.93，95%置信区间：0.37 - 2.33）]中这种关联并不明显。
我们的研究表明（）感染与CSX风险之间可能存在关联。其致病性在中年个体和一些发展中国家更强。然而，需要更多研究进一步调查早期根除（）是否能降低CSX的发病率，特别是在中年个体和一些发展中国家。
