Ma Hui, Angelone Dario, Guadagno Claudia Nunzia, Andersson-Engels Stefan, Konugolu Venkata Sekar Sanathana
Tyndall National Institute, Biophotonics@Tyndall, Cork, Ireland.
University College Cork, School of Engineering Science, Cork, Ireland.
J Biomed Opt. 2024 Jun;29(Suppl 3):S33312. doi: 10.1117/1.JBO.29.S3.S33312. Epub 2024 Dec 18.
Dynamic phantoms capable of changing optical properties by control are essential for standardizing and calibrating spectroscopy systems such as the pulse oximeter. However, current liquid dynamic phantoms containing human blood have a short shelf life and require complex experimental setups. Some solid dynamic phantoms are influenced by the angular-dependent performance of the liquid crystal display (LCD), some have a low spatial resolution, and some have slow control of optical properties.
We aimed to develop a solid dynamic phantom, which can overcome these obstacles by changing the optical properties rapidly and generating dynamic biological signals.
The absorption properties of the phantom can be controlled in real time by modulating an LCD. A light guide was employed to avoid the angular-dependent performance of the LCD by isolating the scattering top-layer tissue-mimicking silicone phantom from the LCD.
The dynamic phantom was characterized at 940, 660, 530, and 455 nm to create a lookup table. Photoplethysmography signals of different heart rates from 80 to 120 beats per minute were synthesized, and oxygen saturation levels at 86%, 90%, 95%, and 100% were generated at multiple wavelengths.
The design, characterization, and potential applications of the dynamic phantom have been presented. This dynamic phantom can simulate various biological signals by applying corresponding modulation signals and has the potential to calibrate and validate pulse oximeter, imaging, and spectroscopy systems.
能够通过控制改变光学特性的动态体模对于诸如脉搏血氧仪等光谱系统的标准化和校准至关重要。然而，当前含有人血的液体动态体模保质期短且需要复杂的实验装置。一些固体动态体模受液晶显示器（LCD）角度依赖性性能的影响，一些空间分辨率低，还有一些对光学特性的控制缓慢。
我们旨在开发一种固体动态体模，它可以通过快速改变光学特性并生成动态生物信号来克服这些障碍。
通过调制液晶显示器可以实时控制体模的吸收特性。采用光导将散射顶层组织模拟硅胶体模与液晶显示器隔离，以避免液晶显示器的角度依赖性性能。
在940、660、530和455纳米对动态体模进行表征以创建查找表。合成了每分钟80至120次不同心率的光电容积脉搏波信号，并在多个波长下生成了86%、90%、95%和100%的血氧饱和度水平。
介绍了动态体模的设计、表征和潜在应用。这种动态体模可以通过施加相应的调制信号来模拟各种生物信号，并且有潜力校准和验证脉搏血氧仪、成像和光谱系统。
