Ntombela Lindokuhle, Adeleye Bamise, Chetty Naven
School of Chemistry and Physics, University of KwaZulu-Natal, Private Bag X01, Scottsville, 3209, South Africa.
Heliyon. 2020 Mar 21;6(3):e03602. doi: 10.1016/j.heliyon.2020.e03602. eCollection 2020 Mar.
The rapid development of new optical imaging techniques is dependent on the availability of low-cost and easily reproducible standards for technique validation. This work describes a low-cost fabrication process of an agar gel-based phantom that may accurately simulate the optical properties of different human tissues at 532 and 630nm wavelengths. It was designed to match the optical properties of the brain, bladder wall, and lung tissues. These low-cost phantoms use agar powders dissolved in water as the bulk matrix. The latter is loaded with varying amounts of India ink, and aluminium oxide AlO particles for optical absorption and scattering targets. The optical properties (absorption and scattering coefficients), the primary design factor and critical parameters of these phantoms were deduced from measurements of the total attenuation coefficients . It is anticipated that the constructed tissue phantoms have the potential to be used as a reference standard since it's possible to preserve the optical properties in a period exceeding two years, under ideal storage conditions.
新型光学成像技术的快速发展依赖于用于技术验证的低成本且易于重现的标准。这项工作描述了一种基于琼脂凝胶的体模的低成本制造工艺，该体模可以在532和630nm波长下准确模拟不同人体组织的光学特性。它旨在匹配脑、膀胱壁和肺组织的光学特性。这些低成本体模使用溶解在水中的琼脂粉作为主体基质。后者加载了不同量的印度墨水和氧化铝AlO颗粒，用于光学吸收和散射目标。这些体模的光学特性（吸收和散射系数）、主要设计因素和关键参数是通过测量总衰减系数推导出来的。预计所构建的组织体模有潜力用作参考标准，因为在理想储存条件下，其光学特性有可能在超过两年的时间内得以保持。
