Thoraval Léa, Varin-Simon Jennifer, Ohl Xavier, Velard Frédéric, Reffuveille Fany, Tang-Fichaux Min
Université de Reims Champagne-Ardenne, BIOS, Reims, France.
Université de Reims Champagne-Ardenne, CHU Reims, BIOS, Service D'Orthopédie et Traumatologie, Reims, France.
Res Microbiol. 2025 Mar-Jun;176(3-4):104265. doi: 10.1016/j.resmic.2024.104265. Epub 2024 Dec 17.
Cutibacterium acnes is a commensal Gram-positive anaerobic bacterium that can also act as an opportunistic pathogen in various diseases, particularly in prosthetic joint infections (PJI). Throughout this review, we delve into the current understanding of the intricate interactions between C. acnes and host cells and discuss bacterial persistence in the host. C. acnes colonization and subsequent PJI set-up represent complex processes involving bacterial adhesion, immune recognition, and host response mechanisms. We highlight existing knowledge and gaps in specific host-pathogen interactions and stress the importance of acquiring additional information to develop targeted strategies for preventing and treating C. acnes-related PIJ.
痤疮丙酸杆菌是一种共生的革兰氏阳性厌氧菌，它也可在多种疾病中作为机会致病菌，尤其是在人工关节感染（PJI）中。在本综述中，我们深入探讨了目前对痤疮丙酸杆菌与宿主细胞之间复杂相互作用的理解，并讨论了该细菌在宿主体内的持续存在情况。痤疮丙酸杆菌的定植以及随后的人工关节感染的发生是涉及细菌黏附、免疫识别和宿主反应机制的复杂过程。我们强调了特定宿主-病原体相互作用方面的现有知识和差距，并强调获取更多信息以制定预防和治疗痤疮丙酸杆菌相关人工关节感染的靶向策略的重要性。
