Mo William, Vaiana Christopher A, Myers Chris J
Draper Scholar, The Charles Stark Draper Laboratory, Inc., 555 Technology Square, Cambridge, MA, USA.
Department of Electrical, Computer, and Energy Engineering, University of Colorado Boulder, 1111 Engineering Dr, Boulder, CO, USA.
Nat Commun. 2024 Dec 19;15(1):10699. doi: 10.1038/s41467-024-55436-y.
Modern biotechnology necessitates robust biosecurity protocols to address the risk of engineered biological threats. Current efforts focus on screening DNA and rejecting the synthesis of dangerous elements but face technical and logistical barriers. Screening should integrate into a broader strategy that addresses threats at multiple stages of development and deployment. The success of this approach hinges upon reliable detection, characterization, and attribution of engineered DNA. Recent advances notably aid the potential to both develop threats and analyze them. However, further work is needed to translate developments into biosecurity applications. This work reviews cutting-edge methods for DNA analysis and recommends avenues to improve biosecurity in an adaptable manner.
现代生物技术需要强有力的生物安全协议来应对基因工程生物威胁的风险。目前的努力集中在筛选DNA并拒绝合成危险元素，但面临技术和后勤方面的障碍。筛选应纳入一个更广泛的战略，该战略在开发和部署的多个阶段应对威胁。这种方法的成功取决于对基因工程DNA的可靠检测、表征和溯源。最近的进展尤其有助于开发威胁和分析威胁的潜力。然而，需要进一步开展工作，将这些进展转化为生物安全应用。本文综述了DNA分析的前沿方法，并建议以适应性方式改善生物安全的途径。
