Cutlip R C, Lehmkuhl H D, Wood R L, Brogden K A
Am J Vet Res. 1985 Jan;46(1):65-8.
Chronic nonsuppurative arthritis developed in carpal and tarsal joints of border Leicester sheep that were naturally or experimentally infected with ovine progressive pneumonia (OPP) virus. Clinical signs of arthritis began at 1 to 6.2 years of age (1 to 5.7 years after inoculation of OPP virus) and slowly progressed in severity until the sheep died or were killed. The joint lesions were characterized by edema, hyperemia, hyperplasia, and necrosis of the synovial membrane; by necrosis and erosion of articular bone; by necrosis and fibrosis of subchondral bone; and by extensive periarticular fibrosis. The OPP virus alone was isolated from arthritic joints. In 7 of 14 sheep, the arthritis was associated with interstitial pneumonitis induced by the virus. Therefore, it was concluded that OPP virus was the cause of arthritis in this group of sheep.
在自然感染或实验性感染绵羊进行性肺炎（OPP）病毒的边区莱斯特绵羊的腕关节和跗关节中，出现了慢性非化脓性关节炎。关节炎的临床症状始于1至6.2岁（接种OPP病毒后1至5.7年），病情严重程度逐渐缓慢进展，直至绵羊死亡或被宰杀。关节病变的特征为滑膜水肿、充血、增生和坏死；关节骨坏死和侵蚀；软骨下骨坏死和纤维化；以及广泛的关节周围纤维化。仅从关节炎关节中分离出了OPP病毒。在14只绵羊中的7只中，关节炎与该病毒引起的间质性肺炎有关。因此，得出结论，OPP病毒是这群绵羊关节炎的病因。
