Huang Yong, Wang Yingying, Su Huiyi, Zhang Yao
Department of Urology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China.
Department of Oncology, Chongqing Jiulongpo District People's Hospital, Chongqing, 400050, China.
BMC Psychiatry. 2024 Dec 20;24(1):936. doi: 10.1186/s12888-024-06302-0.
The association between depression and serum total prostate-specific antigen (PSA) concentrations remains unclear. To explore whether there is a relationship between depression and PSA in American males without prostate cancer (PCa), according to the National Health and Nutrition Examination Survey (NHANES) database.
Three biennial cycles of survey data from 2005 to 2010 were used in our study. Multivariate adjusted regression analysis, stratified analysis, trend testing, smooth curve fitting and multiple imputation (MI) were our main research methods. Depression was assessed by the Patient Health Questionnaire-9 (PHQ-9).
The study included a total of 4185 participants. After adjusting all covariates, whether depression was used as a continuous [β = -0.038; 95% confidence interval (CI): -0.059, -0.017; P < 0.001] or categorical variable (P for trend = 0.001), especially in the mild [β = -0.239; 95% CI: -0.473, -0.006; P = 0.044)] and moderate [β = -0.499; 95% CI: -0.907, -0.092; P = 0.016)] depression groups, it was associated with a decrease in serum PSA concentrations. Smoothing curve fitting found the presence of a linear relationship, with PSA reduced by 0.038 ng/ml or 0.026 ng/ml (log-2 transformed total PSA) for each additional unit of depression score. Similar results were obtained for complete data after MI or data categorized by depressive symptoms.
Depression score is inversely correlated with serum total PSA concentrations among American men, and there is an interaction between depression and myocardial infarction.
Not applicable.
抑郁症与血清总前列腺特异性抗原（PSA）浓度之间的关联仍不明确。为了根据美国国家健康与营养检查调查（NHANES）数据库探究美国无前列腺癌（PCa）男性中抑郁症与PSA之间是否存在关系。
我们的研究使用了2005年至2010年三个两年周期的调查数据。多变量调整回归分析、分层分析、趋势检验、平滑曲线拟合和多重填补（MI）是我们的主要研究方法。抑郁症通过患者健康问卷-9（PHQ-9）进行评估。
该研究共纳入4185名参与者。在调整所有协变量后，无论抑郁症被用作连续变量[β = -0.038；95%置信区间（CI）：-0.059，-0.017；P < 0.001]还是分类变量（趋势P值 = 0.001），尤其是在轻度[β = -0.239；95% CI：-0.473，-0.006；P = 0.044]和中度[β = -0.499；95% CI：-0.907，-0.092；P = 0.016]抑郁症组中，它都与血清PSA浓度降低相关。平滑曲线拟合发现存在线性关系，抑郁症评分每增加一个单位，PSA降低0.038 ng/ml或0.026 ng/ml（对数2转换后的总PSA）。MI后的完整数据或按抑郁症状分类的数据也得到了类似结果。
在美国男性中，抑郁症评分与血清总PSA浓度呈负相关，且抑郁症与心肌梗死之间存在相互作用。
不适用。
