Okan Kasım, Kural Ragıp Fatih, Demir Meryem, Cot Furkan, Dinckal Mustafa, Altay Sevgi, Gökmen Nihal Mete
Department of Internal Medicine, Division of Allergy and Immunology, Ege University, Izmir, Turkey.
Department of Urology, Ege University, Izmir, Turkey.
J Med Case Rep. 2024 Dec 21;18(1):632. doi: 10.1186/s13256-024-04986-2.
Postorgasmic illness syndrome is characterized by flu, rhinitis, conjunctivitis, loss of appetite, muscle weakness, and fatigue after ejaculation, lasting 2-7 days. The multidisciplinary treatment approach, incorporating omalizumab and antidepressants, has rarely been documented in literature.
In this article, we present the case of a 33-year-old single Turkish male with postorgasmic illness syndrome, characterized by typical clinical symptoms and a positive autologous semen test. Notably, his serum estrogen and progesterone levels were elevated. The patient's Beck anxiety score was 42 points, the depression scale score was 37, and suicidal thoughts. Fresh autologous semen taken at the hospital was diluted with 0.9% saline, and prick and intradermal skin tests were performed.
The patient's symptoms improved significantly with the combination of omalizumab and escitalopram. This case not only provides a new perspective on the management of postorgasmic illness syndrome but also highlights the potential roles of allergic, psychiatric, and endocrinological mechanisms in the etiology and treatment of this complex condition.
性高潮后疾病综合征的特征为射精后出现流感样症状、鼻炎、结膜炎、食欲不振、肌肉无力和疲劳，持续2至7天。文献中很少有关于将奥马珠单抗和抗抑郁药纳入多学科治疗方法的记载。
在本文中，我们介绍了一名33岁的单身土耳其男性患性高潮后疾病综合征的病例，其具有典型的临床症状且自体精液检测呈阳性。值得注意的是，他的血清雌激素和孕酮水平升高。患者的贝克焦虑评分为42分，抑郁量表评分为37分，并有自杀念头。在医院采集的新鲜自体精液用0.9%生理盐水稀释后，进行了点刺和皮内皮肤试验。
奥马珠单抗和艾司西酞普兰联合使用后，患者症状显著改善。该病例不仅为性高潮后疾病综合征的管理提供了新视角，还突出了过敏、精神和内分泌机制在这一复杂病症的病因和治疗中的潜在作用。
