Findlay Jacqueline, Nordmann Patrice, Stephan Roger, Poirel Laurent
Medical and Molecular Microbiology, Faculty of Science and Medicine, University of Fribourg, Fribourg, Switzerland.
Institute for Microbiology, University Hospital Lausanne, Lausanne, Switzerland.
Eur J Clin Microbiol Infect Dis. 2025 Mar;44(3):759-762. doi: 10.1007/s10096-024-04972-y. Epub 2024 Dec 21.
Proteus mirabilis is a Gram-negative bacterium found in the environment and also forms part of the commensal flora in the gastrointestinal tract of both humans and animals. P. mirabilis can cause a wide variety of infections, however it does not harbor any intrinsic β-lactamase genes and as such usually exhibits full susceptibility to β-lactams with the exception of imipenem, to which it is naturally resistant. OXA-23 enzymes are carbapenem-hydrolyzing class D β-lactamases and are usually the main cause of acquired resistance to carbapenems in Acinetobacter baumannii but have recently been reported in P. mirabilis in France. In this report we describe the emergence of OXA-23-producing P. mirabilis clinical isolates from Switzerland.
奇异变形杆菌是一种革兰氏阴性菌，存在于环境中，也是人和动物胃肠道共生菌群的一部分。奇异变形杆菌可引起多种感染，然而它不携带任何内在的β-内酰胺酶基因，因此通常对β-内酰胺类药物完全敏感，但亚胺培南除外，它对亚胺培南天然耐药。OXA-23酶是碳青霉烯水解D类β-内酰胺酶，通常是鲍曼不动杆菌获得性碳青霉烯耐药的主要原因，但最近在法国的奇异变形杆菌中也有报道。在本报告中，我们描述了瑞士产OXA-23奇异变形杆菌临床分离株的出现情况。
