Pote Manasi S, Gacche Rajesh N
Tumor Biology Laboratory, Department of Biotechnology, Savitribai Phule Pune University, Pune, 411 007, (MS), India.
Tumor Biology Laboratory, Department of Biotechnology, Savitribai Phule Pune University, Pune, 411 007, (MS), India.
Arch Biochem Biophys. 2025 Feb;764:110277. doi: 10.1016/j.abb.2024.110277. Epub 2024 Dec 19.
Exosomes are membrane-bound extracellular vesicles that play a role in exchanging biological products across membranes and serve as intermediaries in intercellular communication to maintain normal homeostasis. Numerous molecules, including lipids, proteins, and nucleic acids are enclosed in exosomes. Exosomes are constantly released into the extracellular environment and exhibit distinct characteristics based on the secreted cells that produce them. Exosome-mediated cell-to-cell communication has reportedly been shown to affect multiple cancer hallmarks, such as immune response modulation, pre-metastatic niche formation, angiogenesis, stromal cell reprogramming, extracellular matrix architecture remodeling, or even drug resistance, and eventually the development and metastasis of cancer cells. Exosomes can be used as therapeutic targets and possible diagnostic biomarkers by selectively loading oncogenic molecules into them. We highlight the important roles that exosomes play in cancer development in this review, which may lead to the development of fresh approaches for future clinical uses.
外泌体是膜结合的细胞外囊泡，在跨膜交换生物产物中发挥作用，并作为细胞间通讯的中介以维持正常的内环境稳定。外泌体中包裹着众多分子，包括脂质、蛋白质和核酸。外泌体不断释放到细胞外环境中，并根据产生它们的分泌细胞表现出不同的特征。据报道，外泌体介导的细胞间通讯已被证明会影响多种癌症特征，如免疫反应调节、前转移微环境形成、血管生成、基质细胞重编程、细胞外基质结构重塑，甚至耐药性，最终影响癌细胞的发展和转移。通过向外泌体中选择性加载致癌分子，外泌体可作为治疗靶点和潜在的诊断生物标志物。在本综述中，我们强调了外泌体在癌症发展中所起的重要作用，这可能会为未来的临床应用带来新方法的发展。
