Liu Yao-Lin, Hsieh Yi-Ting, Chen Ta-Fu, Chiou Jeng-Min, Tsai Min-Kuang, Chen Jen-Hau, Chen Yen-Ching
Department of Ophthalmology, Far Eastern Memorial Hospital, New Taipei City, Taiwan.
Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei, Taiwan.
Alzheimers Dement (Amst). 2018 Nov 12;11:19-27. doi: 10.1016/j.dadm.2018.10.006. eCollection 2019 Dec.
Thinning of optical coherence tomography-measured retinal nerve fiber layer thickness and ganglion cell-inner plexiform layer (GC-IPL) thickness has been found in patients with Alzheimer's disease. However, the association of these retinal markers and cognition in nondemented elders may not be linear.
This cross-sectional study included 227 community-dwelling elders (age 65+ years). Multivariable regression analyses were performed to investigate the association between retinal nerve fiber layer/GC-IPL and global/domain-specific cognition.
The performance of global cognition decreased as mean GC-IPL of bilateral eyes deviated from the sample mean (77.5 μm) (quadratic GC-IPL: β = -0.49 × 10; 95% confidence interval: -0.74 × 10 to -0.23 × 10). Similar associations were also found for logical memory. No significant association was observed between retinal nerve fiber layer and cognition.
Either thinning or thickening of GC-IPL was associated with poor cognition in nondemented elderly (a U-shaped association). GC-IPL may serve as a noninvasive preclinical predictor of Alzheimer's disease.
在阿尔茨海默病患者中发现，光学相干断层扫描测量的视网膜神经纤维层厚度和神经节细胞-内丛状层（GC-IPL）厚度变薄。然而，在未患痴呆症的老年人中，这些视网膜标志物与认知之间的关联可能并非呈线性。
这项横断面研究纳入了227名社区居住的老年人（年龄65岁及以上）。进行多变量回归分析以研究视网膜神经纤维层/GC-IPL与整体/特定领域认知之间的关联。
随着双眼平均GC-IPL偏离样本均值（77.5μm），整体认知表现下降（二次GC-IPL：β = -0.49×10；95%置信区间：-0.74×10至-0.23×10）。在逻辑记忆方面也发现了类似的关联。视网膜神经纤维层与认知之间未观察到显著关联。
GC-IPL变薄或变厚均与未患痴呆症老年人的认知能力差有关（呈U形关联）。GC-IPL可能作为阿尔茨海默病的一种非侵入性临床前预测指标。
