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传统骨肉瘤的最新进展

Update on Conventional Osteosarcoma.

作者信息

Teixeira Luiz Eduardo Moreira, Guedes Alex, Nakagawa Suely Akiko, Fonseca Karine Corrêa, Lima Eduardo Ribeiro

机构信息

Departamento do Aparelho Locomotor, Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brasil.

Grupo de Oncologia Ortopédica, Hospital Santa Izabel, Santa Casa de Misericórdia da Bahia, Salvador, BA, Brasil.

出版信息

Rev Bras Ortop (Sao Paulo). 2024 Jan 29;59(6):e815-e820. doi: 10.1055/s-0043-1771483. eCollection 2024 Dec.

DOI:10.1055/s-0043-1771483
PMID:39711636
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11663062/
Abstract

Conventional osteosarcoma is a high-grade malignant tumor characterized by the production of osteoid matrix by malignant osteoblasts. It typically affects the long bones of children and adolescents. Treatment includes systemic chemotherapy and a local surgical approach with wide resection. Recent advances in oncology concepts, imaging, surgical planning, and cancer treatment protocols allow for improved survival and a higher limb preservation rate. This paper addresses the current status regarding the incidence, pathology, treatment, and prognosis of conventional high-grade osteosarcoma.

摘要

传统骨肉瘤是一种高级别恶性肿瘤，其特征是恶性成骨细胞产生类骨质基质。它通常影响儿童和青少年的长骨。治疗方法包括全身化疗和采用广泛切除的局部手术方法。肿瘤学概念、影像学、手术规划和癌症治疗方案的最新进展提高了生存率并提高了保肢率。本文阐述了传统高级别骨肉瘤在发病率、病理学、治疗和预后方面的现状。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/135b/11663062/12c485dd4f0b/10-1055-s-0043-1771483-i2200218pt-3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/135b/11663062/75377c64bd11/10-1055-s-0043-1771483-i2200218en-1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/135b/11663062/2becbc6ddeed/10-1055-s-0043-1771483-i2200218en-2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/135b/11663062/73b6053e9e16/10-1055-s-0043-1771483-i2200218en-3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/135b/11663062/13a7b93b30d4/10-1055-s-0043-1771483-i2200218pt-1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/135b/11663062/de1a0716b807/10-1055-s-0043-1771483-i2200218pt-2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/135b/11663062/12c485dd4f0b/10-1055-s-0043-1771483-i2200218pt-3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/135b/11663062/75377c64bd11/10-1055-s-0043-1771483-i2200218en-1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/135b/11663062/2becbc6ddeed/10-1055-s-0043-1771483-i2200218en-2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/135b/11663062/73b6053e9e16/10-1055-s-0043-1771483-i2200218en-3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/135b/11663062/13a7b93b30d4/10-1055-s-0043-1771483-i2200218pt-1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/135b/11663062/de1a0716b807/10-1055-s-0043-1771483-i2200218pt-2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/135b/11663062/12c485dd4f0b/10-1055-s-0043-1771483-i2200218pt-3.jpg

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Cancer. 2022 Jun 1;128(11):2107-2118. doi: 10.1002/cncr.34163. Epub 2022 Feb 28.
3
Updating on Bone and Soft Tissue Sarcomas Staging.骨与软组织肉瘤分期的更新
Rev Bras Ortop (Sao Paulo). 2021 Aug;56(4):411-418. doi: 10.1055/s-0040-1710331. Epub 2020 Sep 30.
4
Advances in targeted therapy for osteosarcoma based on molecular classification.基于分子分类的骨肉瘤靶向治疗进展。
Pharmacol Res. 2021 Jul;169:105684. doi: 10.1016/j.phrs.2021.105684. Epub 2021 May 19.
5
Surgical Advances in Osteosarcoma.骨肉瘤的外科进展
Cancers (Basel). 2021 Jan 21;13(3):388. doi: 10.3390/cancers13030388.
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Immunotherapy for osteosarcoma: Fundamental mechanism, rationale, and recent breakthroughs.骨肉瘤的免疫治疗：基础机制、原理和最新突破。
Cancer Lett. 2021 Mar 1;500:1-10. doi: 10.1016/j.canlet.2020.12.024. Epub 2020 Dec 23.
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Aerosolized Chemotherapy for Osteosarcoma.雾化化疗治疗骨肉瘤。
Adv Exp Med Biol. 2020;1257:67-73. doi: 10.1007/978-3-030-43032-0_6.
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Temozolomide and etoposide combination for the treatment of relapsed osteosarcoma.替莫唑胺与依托泊苷联合治疗骨肉瘤复发。
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