Yadav Trupti, Varadharajulu G, Gudur Rashmi
Department of Oncologic Physiotherapy, Krishna College of Physiotherapy, Krishna Vishwa Vidyapeeth (Deemed to be University), Karad, IND.
Department of Neurosciences, Krishna College of Physiotherapy, Krishna Vishwa Vidyapeeth (Deemed to be University), Karad, IND.
Cureus. 2024 Nov 22;16(11):e74214. doi: 10.7759/cureus.74214. eCollection 2024 Nov.
Introduction A common side effect post chemotherapy is chemotherapy-induced peripheral neuropathy (CIPN). The purpose of this study was to investigate the effect of a multimodal exercise program compared to standard physical therapy in treating CIPN symptoms and improving daily living skills. Aim The aim of this study was to evaluate the effect of multimodal therapeutic exercises and their role in mitigating CIPN symptoms on the neuropathy score and instrumental activities of daily living. Methodology Seventy-eight participants were divided into two groups: multimodal exercise program (Group A) and standard physical therapy (Group B) who fulfilled the inclusion criteria of age 25-55 years with CIPN (grade 2 or 3). Pre- and post-assessment was done using the modified Total Neuropathy Score (mTNS) and Lawton Instrumental Activities of Daily Living Scale (L-IADL). Results A significant improvement in the mTNS was seen in Group A (14.68 ± 1.66 to 7.03 ± 1.49, p<0.0001) compared to Group B (14.98 ± 1.54 to 13.66 ± 1.34, p=0.00116). L-IADL scores also showed more improvement in Group A (7.54 to 11.23, p<0.0001) versus Group B (5.51 to 7.35, p=0.001). A statistically significant improvement was seen (p<0.0001) for both outcome measures post-intervention. Conclusion A superior efficacy was demonstrated by the multimodal exercise program demonstrated in reducing CIPN symptoms and improving functional outcomes compared to standard physical therapy. These findings suggest that comprehensive, multimodal exercise interventions may be more effective in managing CIPN and enhancing quality of life for cancer patients undergoing neurotoxic chemotherapy.
引言 化疗后的一种常见副作用是化疗引起的周围神经病变（CIPN）。本研究的目的是调查多模式运动计划与标准物理治疗相比在治疗CIPN症状和提高日常生活技能方面的效果。
目的 本研究的目的是评估多模式治疗性运动的效果及其在减轻CIPN症状方面对神经病变评分和日常生活工具性活动的作用。
方法 78名参与者被分为两组：多模式运动计划组（A组）和标准物理治疗组（B组），他们符合年龄在25至55岁且患有CIPN（2级或3级）的纳入标准。使用改良的总神经病变评分（mTNS）和洛顿日常生活工具性活动量表（L-IADL）进行干预前和干预后的评估。
结果 与B组（14.98±1.54至13.66±1.34，p = 0.00116）相比，A组的mTNS有显著改善（14.68±1.66至7.03±1.49，p<0.0001）。A组的L-IADL评分也比B组有更大改善（7.54至11.23，p<0.0001）（5.51至7.35，p = 0.001）。干预后两种结局指标均有统计学意义的改善（p<0.0001）。
结论 与标准物理治疗相比，多模式运动计划在减轻CIPN症状和改善功能结局方面显示出更高的疗效。这些发现表明，全面的多模式运动干预可能在管理CIPN和提高接受神经毒性化疗的癌症患者的生活质量方面更有效。
