Firooznia Mohammad Amin, Rahimlou Mehran, Sekhavati Eghbal, Motazedian Mohammadreza, Tabrizi Reza
Student research committee, Fasa University of Medical Sciences, Fasa, Iran.
Department of Nutrition, School of Public Health, Zanjan University of Medical Sciences, Zanjan, Iran.
Front Nutr. 2024 Dec 6;11:1476122. doi: 10.3389/fnut.2024.1476122. eCollection 2024.
Hypertension (HTN) is a prevalent condition associated with numerous cardiovascular and non-cardiac complications. Lifestyle interventions, including dietary adjustments, offer promising avenues for hypertension management. However, the precise relationship between dietary antioxidants and hypertension risk necessitates further investigation. This study aimed to elucidate the association between the Dietary Antioxidant Index (DAI) and hypertension risk using a nested case-control design.
A matched nested case-control study was conducted within the Fasa Adult Cohort Study (FACS), comprising 975 participants aged 35-70 years. Cases ( = 325) were hypertensive patients, while controls ( = 650) were individuals without hypertension, matched for sex and age. Dietary intake was assessed using a validated food frequency questionnaire, and DAI was computed based on standardized intake of antioxidants. Conditional logistic regression models were employed to evaluate the association between DAI and hypertension risk, adjusting for confounding variables.
A significant inverse correlation was observed between DAI and hypertension risk across all models (OR = 0.89; 95% CI = 0.86-0.93, < 0.001). This association remained robust after adjusting for potential confounders, including BMI, smoking, lipid profile, blood glucose levels, and educational status. In conclusion, higher DAI values were associated with a reduced risk of hypertension, highlighting the potential benefits of antioxidant-rich diets in hypertension prevention.
These findings underscore the importance of dietary interventions as a complementary approach to hypertension management.
高血压（HTN）是一种常见疾病，与多种心血管和非心血管并发症相关。包括饮食调整在内的生活方式干预为高血压管理提供了有前景的途径。然而，饮食抗氧化剂与高血压风险之间的确切关系需要进一步研究。本研究旨在采用巢式病例对照设计阐明饮食抗氧化剂指数（DAI）与高血压风险之间的关联。
在法萨成人队列研究（FACS）中进行了一项匹配的巢式病例对照研究，该研究包括975名年龄在35 - 70岁的参与者。病例组（n = 325）为高血压患者，对照组（n = 650）为无高血压的个体，按性别和年龄进行匹配。使用经过验证的食物频率问卷评估饮食摄入量，并根据抗氧化剂的标准化摄入量计算DAI。采用条件逻辑回归模型评估DAI与高血压风险之间的关联，并对混杂变量进行调整。
在所有模型中均观察到DAI与高血压风险之间存在显著的负相关（OR = 0.89；95% CI = 0.86 - 0.93，P < 0.001）。在调整了潜在混杂因素（包括体重指数、吸烟、血脂谱、血糖水平和教育程度）后，这种关联仍然稳健。总之，较高的DAI值与较低的高血压风险相关，突出了富含抗氧化剂的饮食在预防高血压方面的潜在益处。
这些发现强调了饮食干预作为高血压管理补充方法的重要性。
