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在美国有慢性消耗病病例报告地区的野猪（Sus scrofa）中朊病毒的检测

Detection of Prions in Wild Pigs (Sus scrofa) from Areas with Reported Chronic Wasting Disease Cases, United States.

作者信息

Soto Paulina, Bravo-Risi Francisca, Benavente Rebeca, Stimming Tucker H, Bodenchuk Michael J, Whitley Patrick, Turnage Clint, Spraker Terry R, Greenlee Justin, Telling Glenn, Malmberg Jennifer, Gidlewski Thomas, Nichols Tracy, Brown Vienna R, Morales Rodrigo

出版信息

Emerg Infect Dis. 2025 Jan;31(1):168-173. doi: 10.3201/eid3101.240401.

DOI:10.3201/eid3101.240401
PMID:39714396
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11682794/
Abstract

Using a prion amplification assay, we identified prions in tissues from wild pigs (Sus scrofa) living in areas of the United States with variable chronic wasting disease (CWD) epidemiology. Our findings indicate that scavenging swine could play a role in disseminating CWD and could therefore influence its epidemiology, geographic distribution, and interspecies spread.

摘要

通过朊病毒扩增检测，我们在美国慢性消耗病（CWD）流行病学情况各异的地区，从野猪（Sus scrofa）组织中鉴定出了朊病毒。我们的研究结果表明，食腐猪可能在传播CWD中发挥作用，因此可能影响其流行病学、地理分布和种间传播。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a0b3/11682794/d11c954fc6f3/24-0401-F4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a0b3/11682794/bcc349e85cb3/24-0401-F1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a0b3/11682794/f70a48659c6d/24-0401-F2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a0b3/11682794/7910bc63bd1f/24-0401-F3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a0b3/11682794/d11c954fc6f3/24-0401-F4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a0b3/11682794/bcc349e85cb3/24-0401-F1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a0b3/11682794/f70a48659c6d/24-0401-F2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a0b3/11682794/7910bc63bd1f/24-0401-F3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a0b3/11682794/d11c954fc6f3/24-0401-F4.jpg

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本文引用的文献

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The Zoonotic Potential of Chronic Wasting Disease-A Review.慢性消耗病的人畜共患病潜力——综述
Foods. 2023 Feb 15;12(4):824. doi: 10.3390/foods12040824.
2
Emergence of CWD strains.慢性消耗病（CWD）毒株的出现。
Cell Tissue Res. 2023 Apr;392(1):135-148. doi: 10.1007/s00441-022-03688-9. Epub 2022 Oct 6.
3
Susceptibility of Beavers to Chronic Wasting Disease.海狸对慢性消耗病的易感性。
Biology (Basel). 2022 Apr 26;11(5):667. doi: 10.3390/biology11050667.
4
Experimental Oronasal Transmission of Chronic Wasting Disease Agent from White-Tailed Deer to Suffolk Sheep.慢性消瘦病病原体经白尾鹿经口鼻途径传播至萨福克绵羊的实验研究。
Emerg Infect Dis. 2021 Dec;27(12):3156-3158. doi: 10.3201/eid2712.204978.
5
Mixed ancestry from wild and domestic lineages contributes to the rapid expansion of invasive feral swine.来自野生和家养谱系的混合血统有助于入侵性野猪的快速扩张。
Mol Ecol. 2020 Mar;29(6):1103-1119. doi: 10.1111/mec.15392. Epub 2020 Mar 9.
6
Raccoons accumulate PrP after intracranial inoculation of the agents of chronic wasting disease or transmissible mink encephalopathy but not atypical scrapie.浣熊在颅内接种慢性消耗病或传染性水貂脑病病原体后会积累朊蛋白，但接种非典型羊瘙痒病病原体后则不会。
J Vet Diagn Invest. 2019 Mar;31(2):200-209. doi: 10.1177/1040638718825290. Epub 2019 Jan 29.
7
Experimental Transmission of the Chronic Wasting Disease Agent to Swine after Oral or Intracranial Inoculation.经口或颅内接种后慢性消耗病病原体向猪的实验性传播
J Virol. 2017 Sep 12;91(19). doi: 10.1128/JVI.00926-17. Print 2017 Oct 1.
8
Prion strains in mammals: Different conformations leading to disease.哺乳动物中的朊病毒株：导致疾病的不同构象。
PLoS Pathog. 2017 Jul 6;13(7):e1006323. doi: 10.1371/journal.ppat.1006323. eCollection 2017 Jul.
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First case of chronic wasting disease in Europe in a Norwegian free-ranging reindeer.欧洲首例慢性消耗病出现在挪威一头野生驯鹿身上。
Vet Res. 2016 Sep 15;47(1):88. doi: 10.1186/s13567-016-0375-4.
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Susceptibility of cattle to the agent of chronic wasting disease from elk after intracranial inoculation.颅内接种后牛对来自麋鹿的慢性消耗病病原体的易感性。
J Vet Diagn Invest. 2012 Nov;24(6):1087-93. doi: 10.1177/1040638712461249. Epub 2012 Sep 18.