Emerg Infect Dis. 2021 Dec;27(12):3156-3158. doi: 10.3201/eid2712.204978.
Chronic wasting disease (CWD) is a fatal prion disease of cervids. We examined host range of CWD by oronasally inoculating Suffolk sheep with brain homogenate from a CWD-positive white-tailed deer. Sixty months after inoculation, 1/7 sheep had immunoreactivity against the misfolded form of prion protein in lymphoid tissue. Results were confirmed by mouse bioassay.
慢性消瘦病（CWD）是一种致命的鹿科朊病毒病。我们通过鼻腔接种 CWD 阳性白尾鹿的脑组织匀浆，来检测 CWD 的宿主范围。接种后 60 个月，7 只绵羊中有 1 只的淋巴组织中对朊病毒蛋白的错误折叠形式具有免疫反应性。结果通过小鼠生物测定得到证实。
