Wang Liping, Zhang Yao, Zang Xinyuan, Yang Yiting, Wang Wanting, Zhang Jingbo, Que Yunxiang, Liang Fengxiang, Wang Tiezhu, Zhang Jian, Ma Hongxia, Guan Lili
College of Life Sciences, Engineering Research Center of Bioreactor and Pharmaceutical Development, Ministry of Education, Jilin Agricultural University, Changchun 130118, Jilin, PR China.
Changchun Gaorong Biotechnological Co., Ltd., Changchun 130102, Jilin, PR China.
Food Chem X. 2024 Nov 29;24:102049. doi: 10.1016/j.fochx.2024.102049. eCollection 2024 Dec 30.
() residues polysaccharide (FVRP) is a high molecular weight polysaccharide with diverse bioactivities extracted from residues (FVR). However, high molecular weight polysaccharides have been shown to face significant challenges in crossing the cell membrane barrier, thereby limiting their absorption and application in the body. Therefore, an ultrasonic-assisted HO-Fe method was employed for the first time to degrade FVRP, resulting in the production of a new polysaccharide, FVRPF. Compared with FVRP, there was no significant difference in the main chemical structure of FVRPF, but the monosaccharide composition ratio varied. and FVRPF had lower molecular weight and stronger antioxidant capacity. Moreover, FVRPF could be degraded by human microbiota, modulate gut microbiota composition, and increase the production of total short-chain fatty acids (SCFAs). These findings suggest that FVRPF holds potential as a promising prebiotic for applications in the food and pharmaceutical industries.
()残渣多糖（FVRP）是一种从残渣（FVR）中提取的具有多种生物活性的高分子量多糖。然而，高分子量多糖在穿越细胞膜屏障方面面临重大挑战，从而限制了它们在体内的吸收和应用。因此，首次采用超声辅助HO-Fe法降解FVRP，产生了一种新的多糖FVRPF。与FVRP相比，FVRPF的主要化学结构没有显著差异，但单糖组成比例有所不同。并且FVRPF具有较低的分子量和较强的抗氧化能力。此外，FVRPF可被人体微生物群降解，调节肠道微生物群组成，并增加总短链脂肪酸（SCFA）的产生。这些发现表明，FVRPF作为一种有前途的益生元在食品和制药行业具有应用潜力。
