Tang Chenyao
Department of Stomatology, Yongzhou Central Hospital, Yongzhou, Hunan Province, 425000, China.
Naunyn Schmiedebergs Arch Pharmacol. 2025 May;398(5):4957-4968. doi: 10.1007/s00210-024-03732-1. Epub 2024 Dec 24.
Periodontitis is one of the most common diseases and primary causes of tooth loss. The main factor that causes periodontitis is an overactive host immunological response. An in-depth investigation into the molecular pathways that cause periodontitis can aid in creating novel therapeutic approaches for periodontitis and its related systemic disorders. Several immunologic cell death (ICD) pathways have been implicated in advancing periodontitis. Nevertheless, there is still a substantial lack of understanding surrounding the precise molecular mechanisms of ICD in periodontitis. Additionally, the beneficial feature of ICD in periodontitis, which involves its ability to eliminate pathogens, needs further confirmation. According to this, a comprehensive literature search utilizing the Web of Science™, PubMed®, and Scopus® databases was conducted. Only items published in the English language up until October 2024 were taken into account, and finally, 65 relevant papers were selected to be included in this review. In this article, we present a comprehensive analysis of the processes and outcomes of ICD activation in the progression of periodontitis. Lastly, the present difficulties linked to ICDs as a viable treatment option for periodontitis are emphasized.
牙周炎是最常见的疾病之一，也是牙齿脱落的主要原因。导致牙周炎的主要因素是宿主免疫反应过度活跃。深入研究引发牙周炎的分子途径有助于开发针对牙周炎及其相关全身性疾病的新型治疗方法。几种免疫细胞死亡（ICD）途径与牙周炎的进展有关。然而，对于牙周炎中ICD的确切分子机制仍存在大量认识不足。此外，ICD在牙周炎中的有益特性，即其消除病原体的能力，还需要进一步证实。据此，利用科学网™、PubMed®和Scopus®数据库进行了全面的文献检索。仅考虑截至2024年10月以英文发表的文献，最终筛选出65篇相关论文纳入本综述。在本文中，我们对牙周炎进展过程中ICD激活的过程和结果进行了全面分析。最后，强调了与ICD作为牙周炎可行治疗选择相关的当前困难。
