Safari-Gezaz Meysam, Parhizkar Mojtaba
Department of Condensed Matter Physics, Faculty of Physics, University of Tabriz, 29 Bahman Blvd., Tabriz, Iran.
Heliyon. 2024 Dec 5;10(24):e40990. doi: 10.1016/j.heliyon.2024.e40990. eCollection 2024 Dec 30.
Research on hydroxyapatite (HAP) coatings for bone tissue applications has been investigated for decades due to their significant osteoconductive and bioactivity properties. HAP closely resembles the mineral component of human bone, making it ideal for biomedical applications such as implants. This study investigates the synthesis of hydroxyapatite nanoparticles (HAP-NPs) via the microemulsion method, which is essential for creating HAP coatings on the Ti-6Al-4V substrate. A variety of surfactants, including ionic liquid (IL; 2-hydroxyethyl ammonium octanoate ([HEA]OC)) and sodium lauryl sulfate (SLS), were employed to control the nucleation and crystal growth of HAP-NPs. The synthesized nanoparticles were dispersed in isopropanol and applied to the Ti-6Al-4V using the spin coating technique for creating HAP coatings. The samples were characterized using techniques such as FTIR, HNMR, XRD, FESEM, EDS, and AFM. Tafel and Electrochemical impedance spectroscopy (EIS) analyses were used to evaluate the corrosion resistance of the coatings in a simulated body fluid (SBF). The use of IL as a surfactant led to a significant reduction in nanoparticle size from 37.32 nm to 24.80 nm, which is critical for enhancing the coating's properties. Surface roughness decreased dramatically from 84.28 nm to 12.48 nm, indicating a smoother coating that can improve the adhesion strength of coatings. Electrochemical tests demonstrated improved corrosion resistance of coatings, with the charge transfer resistance (R) for the HAP-0.4 IL coating reaching 7.84 MΩ × cm, compared to 0.11 MΩ × cm for the bare Ti-6Al-4V. [HEA]OC as a surfactant improved the protective quality and uniformity of the HAP-IL coatings and reduced the surface roughness. These results indicate that modifying the surface of Ti-6Al-4V with HAP-IL coatings is a promising approach for enhancing its performance in biomedical applications.
由于其显著的骨传导性和生物活性，用于骨组织应用的羟基磷灰石（HAP）涂层的研究已经开展了数十年。HAP与人体骨骼的矿物质成分非常相似，使其成为植入物等生物医学应用的理想材料。本研究通过微乳液法研究了羟基磷灰石纳米颗粒（HAP-NPs）的合成，这对于在Ti-6Al-4V基体上制备HAP涂层至关重要。使用了多种表面活性剂，包括离子液体（IL；辛酸2-羟乙铵（[HEA]OC））和十二烷基硫酸钠（SLS），来控制HAP-NPs的成核和晶体生长。将合成的纳米颗粒分散在异丙醇中，并使用旋涂技术将其应用于Ti-6Al-4V上以制备HAP涂层。使用FTIR、HNMR、XRD、FESEM、EDS和AFM等技术对样品进行了表征。采用塔菲尔和电化学阻抗谱（EIS）分析来评估涂层在模拟体液（SBF）中的耐腐蚀性。使用IL作为表面活性剂导致纳米颗粒尺寸从37.32 nm显著减小到24.80 nm，这对于提高涂层性能至关重要。表面粗糙度从84.28 nm急剧下降到12.48 nm，表明涂层更光滑，可提高涂层的附着力。电化学测试表明涂层的耐腐蚀性得到改善，HAP-0.4 IL涂层的电荷转移电阻（R）达到7.84 MΩ×cm，而裸Ti-6Al-4V的电荷转移电阻为0.11 MΩ×cm。[HEA]OC作为表面活性剂提高了HAP-IL涂层的防护质量和均匀性，并降低了表面粗糙度。这些结果表明，用HAP-IL涂层修饰Ti-6Al-4V表面是提高其在生物医学应用中性能的一种有前途的方法。
