Shaheen Naila A, Rehan Hina, Moghairi Areej, Gmati Giamal, Damlaj Moussab, Salama Hind, Rather Mushtaq, Mendoza May Anne, Alanazi Abeer, Al Ahmari Bader, Al Zahrani Mohsen, Al-Hejazi Ayman, Alaskar Ahmed S
King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia.
Ministry of the National Guard-Health Affairs, Riyadh, Saudi Arabia.
Front Med (Lausanne). 2022 Jul 28;9:901937. doi: 10.3389/fmed.2022.901937. eCollection 2022.
Hematological parameters are critical in disease diagnosis, management, and monitoring; however, complete blood count (CBC) reference intervals vary across populations. The aim of the current study was to provide the reference ranges of hematological parameters/indices in the healthy adult Saudi population.
A multicenter retrospective cross-sectional study was conducted with a sample of employees who were screened pre-employment from January 2015 to December 2019, at tertiary care hospitals in three regions. Demographic and CBC data were extracted from the electronic health system. The 2.5 and 97.5 percentiles were used to determine the reference intervals.
Of a total of 1,388 participants, 53.82% were male. The majority 96% was less than 40 years old, and 85% were from the Central region. Gender-related differences were observed for the RBC count, Hb, HCT, MCV, MCH, MCHC, and the platelet count. Age-related differences were observed for the RBC, Hb, HCT, and eosinophils. The WBC parameters did not differ by gender or age categories. Region-related differences were observed for the RBC, hemoglobin, HCT, MCV, WBC, and basophils. The platelet count was higher in the female group, the age group 40 years and above, and in the Western region. The prevalence of anemia was high in the female group and the Eastern region. The overall neutropenia rate was 12.8%.
The data from this study provide hematological parameter reference ranges for the adult Saudi population by gender, age, and region. Gender and age-related differences were observed for the hematological parameters. Anemia was more frequent in the female group and the Eastern region. Caution must be taken when comparing or interpreting results from different age groups, gender, region of origin, and ethnicity.
血液学参数在疾病诊断、管理和监测中至关重要；然而，全血细胞计数（CBC）参考区间因人群而异。本研究的目的是提供健康沙特成年人群血液学参数/指标的参考范围。
进行了一项多中心回顾性横断面研究，样本为2015年1月至2019年12月在三个地区的三级护理医院进行入职前筛查的员工。人口统计学和CBC数据从电子健康系统中提取。使用第2.5和第97.5百分位数来确定参考区间。
在总共1388名参与者中，53.82%为男性。大多数（96%）年龄小于40岁，85%来自中部地区。观察到红细胞计数、血红蛋白、血细胞比容、平均红细胞体积、平均红细胞血红蛋白含量、平均红细胞血红蛋白浓度和血小板计数存在性别差异。观察到红细胞、血红蛋白、血细胞比容和嗜酸性粒细胞存在年龄差异。白细胞参数在性别或年龄类别上没有差异。观察到红细胞、血红蛋白、血细胞比容、平均红细胞体积、白细胞和嗜碱性粒细胞存在地区差异。女性组、40岁及以上年龄组和西部地区的血小板计数较高。女性组和东部地区贫血患病率较高。总体中性粒细胞减少率为12.8%。
本研究数据按性别、年龄和地区提供了沙特成年人群的血液学参数参考范围。观察到血液学参数存在性别和年龄差异。女性组和东部地区贫血更为常见。在比较或解释来自不同年龄组、性别、原籍地区和种族的结果时必须谨慎。
