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黑人女性的通用遗传咨询与检测:一种解决乳腺癌差异的风险分层方法。

Universal Genetic Counseling and Testing for Black Women: A Risk-Stratified Approach to Addressing Breast Cancer Disparities.

作者信息

Pleasant Versha A, Merajver Sofia D

机构信息

Department of Obstetrics and Gynecology, University of Michigan, Ann Arbor, MI.

Department of Internal Medicine, Rogel Cancer Center, University of Michigan, Ann Arbor, MI.

出版信息

Clin Breast Cancer. 2025 Apr;25(3):193-197. doi: 10.1016/j.clbc.2024.11.024. Epub 2024 Dec 4.

Abstract

Black women experience disproportionate breast cancer-related mortality, with similar overall incidence to White women. Approaches to address these racial health disparities should be multifaceted. Universal genetic counseling and testing for Black women could represent one dimension of a comprehensive approach in guiding early identification of those more likely to experience higher breast cancer-related mortality. The increased risk of triple-negative breast cancer and greater likelihood of early-onset breast cancer among Black women are 2 major justifications, given that these elements are already preexisting testing criteria per the National Comprehensive Cancer Network. Increasing assessment of breast cancer-related risk in the Black community through universal genetic counseling and testing should be considered to focus enhanced screening and preventive measures in a tailored risk-appropriate context.

摘要

黑人女性乳腺癌相关死亡率过高,总体发病率与白人女性相似。解决这些种族健康差异的方法应该是多方面的。为黑人女性提供普遍的基因咨询和检测可能是综合方法的一个维度,有助于早期识别那些乳腺癌相关死亡风险较高的人群。鉴于根据美国国立综合癌症网络的标准,三阴性乳腺癌风险增加和早发性乳腺癌可能性更大这两个因素已经是现有的检测标准,因此这是两大理由。应考虑通过普遍的基因咨询和检测来加强对黑人社区乳腺癌相关风险的评估,以便在适合个体风险的背景下加强筛查和预防措施。

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本文引用的文献

1
Early-onset cancers: Biological bases and clinical implications.早发性癌症:生物学基础及临床意义。
Cell Rep Med. 2024 Sep 17;5(9):101737. doi: 10.1016/j.xcrm.2024.101737. Epub 2024 Sep 10.
2
A Public Health Emergency: Breast Cancer Among Black Communities in the United States.公共卫生紧急事件:美国黑人群体中的乳腺癌。
Obstet Gynecol Clin North Am. 2024 Mar;51(1):69-103. doi: 10.1016/j.ogc.2023.11.001. Epub 2023 Dec 1.

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