口服营养补充剂对正颌外科手术患者术后营养状况的影响：一项随机临床试验。
Effects of Oral Nutritional Supplement on Postoperative Orthognathic Surgery Patients' Nutritional Status: A Randomised Clinical Trial.
作者信息
Prachasartta Naratorn, Siriwatana Kiti, Trachoo Vorapat, Sapwarobol Suwimol, Chantarasinlapin Praew
机构信息
Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Chulalongkorn University, Bangkok, Thailand.
The Medical Food Research Unit, Department of Nutrition and Dietetics, Faculty of Allied Health Sciences, Chulalongkorn University, Bangkok, Thailand.
出版信息
J Multidiscip Healthc. 2024 Dec 21;17:6059-6070. doi: 10.2147/JMDH.S493361. eCollection 2024.
PURPOSE
Orthognathic surgery often leads to decreased nutrient intake and increased metabolic demands, potentially resulting in muscle mass loss and delayed recovery. The use of oral nutritional supplements (ONS) alongside nutritional counselling has been proposed to mitigate these effects. This study aimed to investigate the impact of ONS on the postoperative nutritional status of patients undergoing orthognathic surgery.
PATIENTS AND METHODS
A 12-week randomized controlled trial was conducted at the Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Chulalongkorn University, Bangkok, Thailand. The recruitment period was extended from July to December 2022 due to unforeseen delays. Patients aged 18 or older, undergoing orthognathic surgery involving at least one jaw, and without metabolic diseases or allergies were included. The intervention group received nutritional counselling and ONS for one-month post-surgery, while the control group received only nutritional counselling. The primary outcome was nutritional status, assessed through anthropometric, biomarker, and muscle strength measurements at various time points.
RESULTS
A total of 28 participants completed the study (control group: n=12, intervention group: n=16). Both groups experienced postoperative weight and muscle mass loss. While the intervention group showed a significantly lower weight loss at two- and four-weeks post-surgery, no significant differences were found in other nutritional status parameters or oral health-related quality of life between the groups after 12 weeks.
CONCLUSION
The addition of ONS to nutritional counselling did not significantly improve the overall nutritional status of orthognathic surgery patients in the long term. Further research is needed to explore more personalized and intensive nutritional interventions to enhance postoperative recovery in this population.
TRIAL REGISTRATION
Thai Clinical Trials Registry, TCTR20220624006. Registered 24 June 2022.
目的
正颌外科手术常导致营养摄入减少和代谢需求增加，可能导致肌肉量减少和恢复延迟。有人提出在营养咨询的同时使用口服营养补充剂（ONS）来减轻这些影响。本研究旨在调查ONS对正颌外科手术患者术后营养状况的影响。
患者与方法
在泰国曼谷朱拉隆功大学牙科学院口腔颌面外科进行了一项为期12周的随机对照试验。由于意外延迟，招募期从2022年7月延长至12月。纳入年龄在18岁及以上、接受涉及至少一侧颌骨的正颌外科手术且无代谢疾病或过敏的患者。干预组在术后接受为期一个月的营养咨询和ONS，而对照组仅接受营养咨询。主要结局是营养状况，通过在不同时间点进行人体测量、生物标志物检测和肌肉力量测量来评估。
结果
共有28名参与者完成了研究（对照组：n = 12，干预组：n = 16）。两组均出现术后体重和肌肉量下降。虽然干预组在术后两周和四周时体重下降明显较低，但12周后两组在其他营养状况参数或口腔健康相关生活质量方面未发现显著差异。
结论
在营养咨询中添加ONS并不能长期显著改善正颌外科手术患者的整体营养状况。需要进一步研究探索更个性化和强化的营养干预措施，以促进该人群的术后恢复。
试验注册
泰国临床试验注册中心，TCTR20220624006。2022年6月24日注册。
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