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本文引用的文献

1
Research progress on insomnia treated by traditional Chinese medicine and acupuncture based on microbial-gut-brain axis theory.基于微生物-肠道-脑轴理论的中医及针刺治疗失眠的研究进展
World J Clin Cases. 2024 Jun 26;12(18):3314-3320. doi: 10.12998/wjcc.v12.i18.3314.
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Hypothalamic-Pituitary-Adrenal Axis and Epilepsy.下丘脑-垂体-肾上腺轴与癫痫
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Acute sleep deprivation exacerbates systemic inflammation and psychiatry disorders through gut microbiota dysbiosis and disruption of circadian rhythms.急性睡眠剥夺通过肠道微生物群失调和昼夜节律紊乱加剧全身炎症和精神疾病。
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Isoliquiritigenin alleviates P. gingivalis-LPS/ATP-induced pyroptosis by inhibiting NF-κB/ NLRP3/GSDMD signals in human gingival fibroblasts.甘草素减轻牙龈卟啉单胞菌脂多糖/三磷酸腺苷诱导的人牙龈成纤维细胞细胞焦亡,通过抑制 NF-κB/NLRP3/GSDMD 信号通路。
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The Gut-Brain Axis: How Microbiota and Host Inflammasome Influence Brain Physiology and Pathology.肠-脑轴:微生物群与宿主炎性小体如何影响脑生理学和病理学
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Autism, Gastrointestinal Symptoms and Modulation of Gut Microbiota by Nutritional Interventions.自闭症、胃肠道症状和营养干预对肠道微生物群的调节。
Nutrients. 2019 Nov 18;11(11):2812. doi: 10.3390/nu11112812.
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The trypanosome-specific proteins FPRC and CIF4 regulate cytokinesis initiation by recruiting CIF1 to the cytokinesis initiation site.锥虫特异性蛋白 FPRC 和 CIF4 通过将 CIF1 募集到胞质分裂起始位点来调节胞质分裂的起始。
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Ciprofloxacin and levofloxacin attenuate microglia inflammatory response via TLR4/NF-kB pathway.环丙沙星和左氧氟沙星通过 TLR4/NF-kB 通路减轻小胶质细胞炎症反应。
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基于微生物-肠道-脑轴理论的中医治疗失眠

Traditional Chinese medicine treatment of insomnia based on microbial-gut-brain axis theory.

作者信息

Wang Xue-Jian

机构信息

Department of Neurosurgery, The Second Affiliated Hospital of Nantong University, Nantong 226000, Jiangsu Province, China.

Department of Neurosurgery, Lueyang People's Hospital, Hanzhong 723000, Shaanxi Province, China.

出版信息

World J Clin Cases. 2024 Dec 26;12(36):6867-6870. doi: 10.12998/wjcc.v12.i36.6867.

DOI:10.12998/wjcc.v12.i36.6867
PMID:39726932
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11531981/
Abstract

In recent years, insomnia has gradually become a common disease in society, which seriously affects people's quality of life. At present, with the deepening of research on intestinal microbiota-gut-brain axis in Western medicine, many studies suggest that regulating the gastrointestinal tract can treat brain-related diseases. It is found that brain-gut-bacteria axis plays an important role in the prevention and treatment of primary insomnia. At present, although the clinical treatment of insomnia with Western medicine can improve the insomnia symptoms of patients to a certain extent, there are still obvious adverse reactions, such as anxiety and depression, drug addiction, , so long-term oral drug therapy cannot be carried out. Traditional Chinese medicine (TCM) and acupuncture techniques have certain therapeutic effects on insomnia. TCM believes that the brain and gastrointestinal system are connected through the meridian, and the pathophysiology is closely related. This paper will discuss the theory and feasibility of TCM for the treatment of insomnia from the pathological relationship between brain-gut axis, intestinal flora and insomnia.

摘要

近年来,失眠已逐渐成为社会中的一种常见疾病,严重影响人们的生活质量。目前,随着西医对肠道微生物群-肠-脑轴研究的深入,许多研究表明调节胃肠道可以治疗与大脑相关的疾病。研究发现,脑-肠-菌轴在原发性失眠的防治中发挥着重要作用。目前,虽然西医对失眠的临床治疗能在一定程度上改善患者的失眠症状,但仍存在明显的不良反应,如焦虑抑郁、药物成瘾等,因此无法进行长期口服药物治疗。中医及针灸技术对失眠有一定的治疗作用。中医认为脑与胃肠系统通过经络相连,病理生理密切相关。本文将从脑-肠轴、肠道菌群与失眠的病理关系探讨中医治疗失眠的理论及可行性。