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波兰接受化疗、自体移植和支持治疗的多发性骨髓瘤患者的疾病特异性主诉:一项横断面研究。

Disease-specific complaints among multiple myeloma patients treated with chemotherapy, autotransplantation and supportive therapy in Poland: a cross-sectional study.

作者信息

Kurek Magdalena, Tatara Tomasz, Świtalski Jakub, Gujski Mariusz, Fronczak Adam

机构信息

Department of Public Health, Faculty of Health Sciences, Medical University of Warsaw, 02-091, Warsaw, Poland.

Department of Health Economics and Medical Law, Faculty of Health Sciences, Medical University of Warsaw, Erazma Ciołka 27, 01-445, Warszawa, Poland.

出版信息

Sci Rep. 2024 Dec 28;14(1):31098. doi: 10.1038/s41598-024-82301-1.

Abstract

Due to its course, multiple myeloma may negatively affect the functioning of patients. Different treatment methods are also associated with patients' varying perception of their health condition. The purpose of this study is to determine the disease-specific complaints among multiple myeloma patients during selected treatment methods-chemotherapy, autologous hematopoietic stem cell transplantation, and supportive therapy. The study group included 246 patients (98 in the chemotherapy group, of which 87 in the autologous hematopoietic stem cell transplantation group and 61 in the supportive therapy group). The study was conducted between August 2020 and December 2021 with the EORTC QLQ-MY20 questionnaire. According to the study results, patients treated with chemotherapy had the highest degree of disease symptom severity and side effects of treatment as well as the lowest assessment of their perspectives for the future. Patients who received supportive treatment had the lowest degree of disease symptom severity and side effects of treatment, and also assessed their body image and future perspectives the highest. Women assessed their future perspectives significantly lower than men. The severity of disease symptoms experienced by patients increases with age.

摘要

由于其病程特点,多发性骨髓瘤可能会对患者的身体机能产生负面影响。不同的治疗方法也与患者对自身健康状况的不同认知相关。本研究的目的是确定在选定的治疗方法(化疗、自体造血干细胞移植和支持治疗)期间,多发性骨髓瘤患者特定疾病的主诉。研究组包括246名患者(化疗组98名,其中自体造血干细胞移植组87名,支持治疗组61名)。该研究于2020年8月至2021年12月期间使用欧洲癌症研究与治疗组织QLQ-MY20问卷进行。根据研究结果,接受化疗的患者疾病症状严重程度和治疗副作用程度最高,对未来前景的评估最低。接受支持治疗的患者疾病症状严重程度和治疗副作用程度最低,对身体形象和未来前景的评估也最高。女性对未来前景的评估明显低于男性。患者经历的疾病症状严重程度随年龄增长而增加。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5455/11680775/16953a46b4ca/41598_2024_82301_Fig1_HTML.jpg

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