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铜纳米颗粒的绿色合成:应对耐药性和癌症治疗挑战的一种有前景的解决方案。

Green synthesis of copper nanoparticles: a promising solution for drug resistance and cancer therapy challenges.

作者信息

Krishna Anand G, Sahana S, Venkatesan H, Arul Vettrivel

机构信息

Department of Organon of medicine, Vinayaka Mission's Homoeopathic Medical College and Hospital, Vinayaka Mission's Research Foundation (DU), Salem, India.

Department of Practice of Medicine, Vinayaka Mission's Homoeopathic Medical College and Hospital, Vinayaka Mission's Research Foundation (DU), Salem, India.

出版信息

J Egypt Natl Canc Inst. 2024 Dec 28;36(1):44. doi: 10.1186/s43046-024-00254-y.

DOI:10.1186/s43046-024-00254-y
PMID:39730977
Abstract

Green synthesis techniques have drawn a lot of interest lately since they are beneficial to the environment and have potential uses in a variety of industries, including biomedicine. Because of their special physicochemical characteristics, copper nanoparticles (CuNPs) have become one of the most interesting options for use in biological applications among nanomaterials. An overview of green synthesis methods for CuNPs is given in this review, along with a discussion of their applications in cancer therapeutics. The benefits and drawbacks of certain green synthesis techniques, such as plant-mediated, microorganism-mediated, and other environmentally friendly processes, are discussed. Moreover, a thorough discussion is given of CuNPs' biological uses, including their antibacterial activity, anticancer potential, drug transport, and bioimaging capabilities. Furthermore, difficulties and prospects for the application of green-synthesised CuNPs in biomedicine are discussed.

摘要

绿色合成技术近年来备受关注,因为它们对环境有益,并且在包括生物医学在内的各种行业中具有潜在用途。由于其特殊的物理化学特性,铜纳米颗粒(CuNPs)已成为纳米材料中生物应用最具吸引力的选择之一。本文综述了CuNPs的绿色合成方法,并讨论了它们在癌症治疗中的应用。讨论了某些绿色合成技术的优缺点,如植物介导、微生物介导和其他环境友好型工艺。此外,还深入讨论了CuNPs的生物学用途,包括它们的抗菌活性、抗癌潜力、药物运输和生物成像能力。此外,还讨论了绿色合成的CuNPs在生物医学应用中的困难和前景。

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本文引用的文献

1
Nanoparticle-Mediated Drug Delivery Systems for Precision Targeting in Oncology.用于肿瘤学精准靶向的纳米颗粒介导药物递送系统
Pharmaceuticals (Basel). 2024 May 24;17(6):677. doi: 10.3390/ph17060677.
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Biomimetic copper-doped polypyrrole nanoparticles induce glutamine metabolism inhibition to enhance breast cancer cuproptosis and immunotherapy.仿生铜掺杂聚吡咯纳米粒子诱导谷氨酰胺代谢抑制增强乳腺癌铜死亡和免疫治疗。
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Exploring the cytotoxicity mechanisms of copper ions and copper oxide nanoparticles in cells from the excretory system.
探讨铜离子和氧化铜纳米颗粒在排泄系统细胞中的细胞毒性机制。
Chemosphere. 2024 Jan;347:140713. doi: 10.1016/j.chemosphere.2023.140713. Epub 2023 Nov 17.
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Nanoparticle-based drug delivery systems targeting cancer cell surfaces.靶向癌细胞表面的基于纳米颗粒的药物递送系统。
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pH-responsive targeted gold nanoparticles for photoacoustic imaging of tumor microenvironments.用于肿瘤微环境光声成像的pH响应型靶向金纳米颗粒。
Nanoscale Adv. 2018 Dec 13;1(2):554-564. doi: 10.1039/c8na00190a. eCollection 2019 Feb 12.
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Green Synthesis and Characterization of Copper Nanoparticles Using Leaves.利用树叶进行铜纳米颗粒的绿色合成与表征
Polymers (Basel). 2021 Dec 13;13(24):4364. doi: 10.3390/polym13244364.
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Nanoparticles for Cancer Therapy: Current Progress and Challenges.用于癌症治疗的纳米颗粒:当前进展与挑战
Nanoscale Res Lett. 2021 Dec 5;16(1):173. doi: 10.1186/s11671-021-03628-6.
8
The 35th Anniversary of the Discovery of EPR Effect: A New Wave of Nanomedicines for Tumor-Targeted Drug Delivery-Personal Remarks and Future Prospects.EPR效应发现35周年:肿瘤靶向药物递送纳米药物新热潮——个人评论与未来展望
J Pers Med. 2021 Mar 22;11(3):229. doi: 10.3390/jpm11030229.
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Review on nanoparticles and nanostructured materials: history, sources, toxicity and regulations.纳米颗粒与纳米结构材料综述:历史、来源、毒性及相关法规
Beilstein J Nanotechnol. 2018 Apr 3;9:1050-1074. doi: 10.3762/bjnano.9.98. eCollection 2018.
10
Silver nanoparticles: A new view on mechanistic aspects on antimicrobial activity.银纳米颗粒:抗菌活性作用机制的新视角。
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