LCR注释数据库：一个关于低复杂度区域功能和结构注释的数据库。

LCRAnnotationsDB: a database of low complexity regions functional and structural annotations.

作者信息

Ziemska-Legiecka Joanna, Jarnot Patryk, Szymańska Sylwia, Błaszczyk Dagmara, Staśczak Alicja, Langer-Macioł Hanna, Lucińska Kinga, Widzisz Karolina, Janas Aleksandra, Słowik Hanna, Śliwińska Wiktoria, Gruca Aleksandra, Grynberg Marcin

机构信息

Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Warsaw, 02-106, Poland.

Department of Computer Networks and Systems, Silesian University of Technology, Gliwice, 44-100, Poland.

出版信息

BMC Genomics. 2024 Dec 27;25(1):1251. doi: 10.1186/s12864-024-10960-5.

DOI:10.1186/s12864-024-10960-5

PMID:39731018

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11674544/

Abstract

Low Complexity Regions (LCRs) are segments of proteins with a low diversity of amino acid composition. These regions play important roles in proteins. However, annotations describing these functions are dispersed across databases and scientific literature. LCRAnnotationsDB aims to consolidate knowledge about LCRs and store relevant annotations in a single place. To unify redundant annotations, we assigned them categories based on similarity in function, protein structure, and biological process. Categories are organized hierarchically by linking them to Gene Ontology terms. The LCRAnnotationsDB database can be accessed at https://lcrannotdb.lcr-lab.org/ .

摘要

低复杂性区域（LCRs）是氨基酸组成多样性较低的蛋白质片段。这些区域在蛋白质中发挥着重要作用。然而，描述这些功能的注释分散在各个数据库和科学文献中。LCRAnnotationsDB旨在整合有关LCRs的知识，并将相关注释存储在一个地方。为了统一冗余注释，我们根据功能、蛋白质结构和生物学过程的相似性为它们分配了类别。通过将类别与基因本体术语链接，对类别进行层次化组织。可通过https://lcrannotdb.lcr-lab.org/访问LCRAnnotationsDB数据库。