Institute of Biomembranes, Bioenergetics and Molecular Biotechnologies, National Research Council (CNR-IBIOM), Bari, Italy.
Department of Biomedical Sciences, University of Padova, Padova, Italy.
Nucleic Acids Res. 2022 Jan 7;50(D1):D480-D487. doi: 10.1093/nar/gkab1082.
The Database of Intrinsically Disordered Proteins (DisProt, URL: https://disprot.org) is the major repository of manually curated annotations of intrinsically disordered proteins and regions from the literature. We report here recent updates of DisProt version 9, including a restyled web interface, refactored Intrinsically Disordered Proteins Ontology (IDPO), improvements in the curation process and significant content growth of around 30%. Higher quality and consistency of annotations is provided by a newly implemented reviewing process and training of curators. The increased curation capacity is fostered by the integration of DisProt with APICURON, a dedicated resource for the proper attribution and recognition of biocuration efforts. Better interoperability is provided through the adoption of the Minimum Information About Disorder (MIADE) standard, an active collaboration with the Gene Ontology (GO) and Evidence and Conclusion Ontology (ECO) consortia and the support of the ELIXIR infrastructure.
蛋白质无序数据库（DisProt，网址：https://disprot.org）是一个主要的数据库，其中包含了文献中手动注释的蛋白质和区域的无序性。我们在此报告 DisProt 版本 9 的最新更新，包括重新设计的网页界面、重构的无序蛋白质本体论（IDPO）、改进的注释过程以及约 30%的显著内容增长。通过新实施的审查过程和对注释者的培训，提供了更高质量和更一致的注释。通过将 DisProt 与 APICURON 集成，为生物注释工作的适当归因和认可提供了更大的注释能力，APICURON 是一个专门的资源。通过采用最小无序信息（MIADE）标准，与基因本体论（GO）和证据与结论本体论（ECO）联盟的积极合作，以及对 ELIXIR 基础设施的支持，提供了更好的互操作性。
