Leipziger L S, Glushko V, DiBernardo B, Shafaie F, Noble J, Nichols J, Alvarez O M
J Am Acad Dermatol. 1985 Feb;12(2 Pt 2):409-19. doi: 10.1016/s0190-9622(85)80004-9.
The effects of two different polymeric wound dressings and a new collagen matrix (CM) implant on the healing and scarring of full-thickness excision wounds were studied in swine. The synthetic polymers comprised an occlusive O2-impermeable hydrocolloid dressing (HCD) and an occlusive O2-permeable polyurethane film (PUF). The CM implant consisted of an acellular collagen sponge fabricated from purified bovine tendon type I collagen. Wounds were evaluated for granulation tissue--production capacity by measuring 14C proline incorporation into collagenase-sensitive protein. Epidermal resurfacing and wound contraction were measured by computerized morphometric image analysis of wounds made on a tattooed grid. In comparison with air-exposed wounds, the relative collagen synthetic capacity was greater in the granulation tissue of wounds treated with HCD, PUF, or CM with occlusion. Both HCD and PUF accelerated by 40% the epidermal resurfacing over the granulating wound bed. Wound contraction was significantly reduced by CM but was not altered by the occlusive dressings.
在猪身上研究了两种不同的聚合物伤口敷料和一种新型胶原蛋白基质（CM）植入物对全层切除伤口愈合和瘢痕形成的影响。合成聚合物包括一种封闭性的不透氧水胶体敷料（HCD）和一种封闭性的透氧聚氨酯薄膜（PUF）。CM植入物由用纯化的牛I型肌腱胶原制成的无细胞胶原海绵组成。通过测量14C脯氨酸掺入胶原酶敏感蛋白来评估伤口的肉芽组织生成能力。通过对纹身网格上的伤口进行计算机形态计量图像分析来测量表皮再上皮化和伤口收缩。与暴露于空气中的伤口相比，用HCD、PUF或CM封闭处理的伤口肉芽组织中的相对胶原合成能力更强。HCD和PUF均使肉芽创面床的表皮再上皮化加速40%。CM显著减少了伤口收缩，但封闭性敷料对其无影响。
