3B's Research Group-Biomaterials, Biodegradables and Biomimetics, University of Minho, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, AvePark, Guimarães, Portugal.
Tissue Eng Part A. 2013 Apr;19(7-8):860-9. doi: 10.1089/ten.TEA.2011.0651. Epub 2013 Feb 19.
Wound management represents a major clinical challenge on what concerns healing enhancement and pain control. The selection of an appropriate dressing plays an important role in both recovery and esthetic appearance of the regenerated tissue. Despite the wide range of available dressings, the progress in the wound care market relies on the increasing interest in using natural-based biomedical products. Herein, a rat wound-dressing model of partial-thickness skin wounds was used to study newly developed chitosan/soy (cht/soy)-based membranes as wound-dressing materials. Healing and repair of nondressed, cht/soy membrane-dressed, and Epigard(®)-dressed wounds were followed macroscopically and histologically for 1 and 2 weeks. cht/soy membranes performed better than the controls, promoting a faster wound repair. Re-epithelialization, observed 1 week after wounding, was followed by cornification of the outermost epidermal layer at the second week of dressing, indicating repair of the wounded tissue. The use of this rodent model, although in impaired healing conditions, may enclose some drawbacks regarding the inevitable wound contraction. Moreover, being the main purpose the evaluation of cht/soy-based membranes' performance in the absence of growth factors, the choice of a clinically relevant positive control was limited to a polymeric mesh, without any growth factor influencing skin healing/repair, Epigard. These new cht/soy membranes possess the desired features regarding healing/repair stimulation, ease of handling, and final esthetic appearance-thus, valuable properties for wound dressings.
伤口管理是一个主要的临床挑战，涉及到促进愈合和控制疼痛。选择合适的敷料在恢复和再生组织的美观外观方面都起着重要作用。尽管有广泛的可用敷料，但伤口护理市场的进展依赖于人们对使用基于天然的生物医学产品的兴趣日益增加。在此，使用大鼠部分厚度皮肤伤口模型来研究新开发的壳聚糖/大豆（cht/soy）基膜作为伤口敷料材料。未处理、cht/soy 膜处理和 Epigard（®）处理的伤口在宏观和组织学上分别随访 1 周和 2 周。cht/soy 膜的效果优于对照组，能更快地促进伤口修复。受伤后 1 周观察到的再上皮化，在第 2 周的敷料处理时被最外层表皮的角化所取代，表明受伤组织的修复。尽管该啮齿动物模型在愈合不良的情况下使用，但可能存在一些不可避免的伤口收缩的缺点。此外，由于主要目的是评估 cht/soy 基膜在没有生长因子的情况下的性能，因此，可选择的临床相关阳性对照仅限于没有任何生长因子影响皮肤愈合/修复的聚合物网，即 Epigard。这些新的 cht/soy 膜具有促进愈合/修复、易于处理和最终美观外观的所需特性，因此对伤口敷料具有重要价值。
