综述用于伤口愈合的基于胶原蛋白的生物材料。
Review collagen-based biomaterials for wound healing.
机构信息
Department of Chemistry, University of Wisconsin-Madison, Madison, WI, 53706.
出版信息
Biopolymers. 2014 Aug;101(8):821-33. doi: 10.1002/bip.22486.
Abstract
With its wide distribution in soft and hard connective tissues, collagen is the most abundant of animal proteins. In vitro, natural collagen can be formed into highly organized, three-dimensional scaffolds that are intrinsically biocompatible, biodegradable, nontoxic upon exogenous application, and endowed with high tensile strength. These attributes make collagen the material of choice for wound healing and tissue engineering applications. In this article, we review the structure and molecular interactions of collagen in vivo; the recent use of natural collagen in sponges, injectables, films and membranes, dressings, and skin grafts; and the on-going development of synthetic collagen mimetic peptides as pylons to anchor cytoactive agents in wound beds.
摘要
胶原蛋白在软、硬结缔组织中广泛分布，是动物蛋白中含量最丰富的一种。在体外，天然胶原蛋白可以形成高度有序的三维支架，具有内在的生物相容性、可生物降解性、外源性应用时无毒、拉伸强度高。这些特性使胶原蛋白成为伤口愈合和组织工程应用的首选材料。本文综述了胶原蛋白在体内的结构和分子相互作用；天然胶原蛋白在海绵、注射剂、薄膜和膜、敷料和皮肤移植物中的最新应用；以及合成胶原模拟肽作为锚固细胞活性物质在伤口床中的支柱的持续发展。
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