Ren Zheng-Ting, Kang Mei, Zhu Li-Yang, Li Ping
Department of Radiation Oncology, The First Affiliated Hospital of Anhui Medical University, Hefei 230022, Anhui Province, China.
Oncology Department of Integrated Traditional Chinese and Western Medicine, The First Affiliated Hospital of Anhui Medical University, Hefei 230022, Anhui Province, China.
World J Gastrointest Surg. 2024 Dec 27;16(12):3772-3779. doi: 10.4240/wjgs.v16.i12.3772.
The global incidence of esophageal cancer (EC) remains high. Despite advancements in medical technology and deeper research into the causes and treatment methods of EC, the effectiveness of treatment for EC is still unsatisfactory. Therefore, it is crucial to address the urgent problem of improving the long-term survival rate of EC patients and providing personalized treatment.
To analyze the survival prognosis and influencing factors of esophageal squamous cell carcinoma (ESCC).
A retrospective analysis was conducted on the clinical data of 115 patients with pT3N0M0 ESCC who underwent radical surgery alone from January 1, 2013, to December 31, 2019. The Kaplan-Meier method was used to evaluate the 1-year, 3-year, and 5-year survival rates and median survival time of the patients. The Cox proportional hazards regression model was used to assess the hazard ratios (HRs) and 95% confidence intervals (95%CIs) of risk factors.
The 1-year, 3-year, and 5-year overall survival (OS) rates for the 115 EC patients analyzed were 85.22%, 50.43%, and 37.48%, respectively. The median OS was 37.00 (95%CI: 24.93-49.07) months, and the median disease-free survival was 21.00 (95%CI: 14.71-27.29) months. Both univariate and multivariate Cox regression analyses revealed that high body mass index (BMI; HR = 1.137, 95%CI: 1.054-1.226), positive perineural invasion (PNI; HR = 13.381, 95%CI: 4.899-36.547), and smoking (HR = 2.415, 95%CI: 1.388-4.203) were independent risk factors for a poor prognosis. In contrast, compared to the upper thoracic location of the tumor, middle thoracic (HR = 0.441, 95%CI: 0.240-0.810) and lower thoracic (HR = 0.328, 95%CI: 0.144-0.750) locations were protective factors.
BMI, tumor location, PNI, and smoking are associated with the prognosis of ESCC patients. This study highlights the prognostic risk factors for T3N0M0 ESCC patients and offers personalized insights for clinical treatment.
食管癌（EC）的全球发病率仍然很高。尽管医疗技术有所进步，对EC的病因和治疗方法的研究也更加深入，但EC的治疗效果仍不尽人意。因此，解决提高EC患者长期生存率和提供个性化治疗这一紧迫问题至关重要。
分析食管鳞状细胞癌（ESCC）的生存预后及影响因素。
对2013年1月1日至2019年12月31日期间仅接受根治性手术的115例pT3N0M0 ESCC患者的临床资料进行回顾性分析。采用Kaplan-Meier法评估患者的1年、3年和5年生存率及中位生存时间。采用Cox比例风险回归模型评估危险因素的风险比（HR）和95%置信区间（95%CI）。
所分析的115例EC患者的1年、3年和5年总生存率（OS）分别为85.22%、50.43%和37.48%。中位OS为37.00（95%CI：24.93 - 49.07）个月，中位无病生存期为21.00（95%CI：14.71 - 27.29）个月。单因素和多因素Cox回归分析均显示，高体重指数（BMI；HR = 1.137，95%CI：1.054 - 1.226）、神经周围侵犯阳性（PNI；HR = 13.381，95%CI：4.899 - 36.547）和吸烟（HR = 2.415，95%CI：1.388 - 4.203）是预后不良的独立危险因素。相比之下，与肿瘤位于胸段上部相比，胸段中部（HR = 0.441，95%CI：0.240 - 0.810）和胸段下部（HR = 0.328，95%CI：0.144 - 0.750）是保护因素。
BMI、肿瘤位置、PNI和吸烟与ESCC患者的预后相关。本研究突出了T3N0M0 ESCC患者的预后危险因素，并为临床治疗提供了个性化见解。
