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SEMA7A预后及免疫作用的泛癌分析

Pan-Cancer Analysis of the Prognostic and Immunological Role of SEMA7A.

作者信息

Yang Lixian, Zhang Shiyu, Zheng Lei, Kong Fanting, Dang Wei, Shen Shipeng, Li Xiaowei, Jia Lining, Zhang Xiaoru, Lu Na

机构信息

Department of Breast Surgery, Xingtai People's Hospital, Xingtai, Hebei, 054000, People's Republic of China.

Medical Research Center, Xingtai Medical College, Xingtai, Hebei, 054000, People's Republic of China.

出版信息

Int J Gen Med. 2024 Dec 25;17:6443-6461. doi: 10.2147/IJGM.S499872. eCollection 2024.

DOI:10.2147/IJGM.S499872
PMID:39735166
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11682669/
Abstract

BACKGROUND

Semaphorin7A (SEMA7A) has been found to regulate both nerve and vessel homeostasis, but its specific role in pan-cancer remains uncertain. This research seeks to delve into the function and clinical relevance of SEMA7A in pan-cancer.

METHODS

Through an analysis of gene expression omnibus and the cancer genome atlas datasets, we investigated the impact of SEMA7A on prognosis and immune regulation across 33 types of tumors. Variations in SEMA7A expression were observed between cancerous and adjacent normal tissues, with a notable correlation between SEMA7A levels and patient prognosis.

RESULTS

Across most cancer types, SEMA7A expression was linked to the infiltration of immune cells, as well as immune checkpoints and other immune regulators. The findings were further confirmed through quantitative real-time polymerase chain reaction analysis of SEMA7A expression in breast cancer. Further, SEMA7A is positively associated with prognosis in different cancers. Additionally, SEMA7A expression was associated with TMB and MSI in some cancer types, while in 15 types of cancer, there was a correlation between SEMA7A expression and DNA methylation. SEMA7A was associated with the expression of multiple immune checkpoint genes and abundance of tumor-infiltrating immune cells across multiple types of cancer.

CONCLUSION

This inaugural pan-cancer examination of SEMA7A sheds light on its prognostic and immunological significance in diverse tumor types, suggesting its potential utility as a biomarker for predicting unfavorable outcomes and immune cell infiltration in cancer.

摘要

背景

已发现信号素7A（SEMA7A）可调节神经和血管稳态，但其在泛癌中的具体作用仍不确定。本研究旨在深入探讨SEMA7A在泛癌中的功能及临床相关性。

方法

通过对基因表达综合数据库和癌症基因组图谱数据集的分析，我们研究了SEMA7A对33种肿瘤预后和免疫调节的影响。观察到癌组织和相邻正常组织中SEMA7A表达的差异，且SEMA7A水平与患者预后之间存在显著相关性。

结果

在大多数癌症类型中，SEMA7A表达与免疫细胞浸润、免疫检查点及其他免疫调节因子相关。通过对乳腺癌中SEMA7A表达进行定量实时聚合酶链反应分析，进一步证实了这些发现。此外，SEMA7A在不同癌症中与预后呈正相关。另外，在某些癌症类型中，SEMA7A表达与肿瘤突变负荷（TMB）和微卫星不稳定性（MSI）相关，而在15种癌症中，SEMA7A表达与DNA甲基化之间存在相关性。在多种类型癌症中，SEMA7A与多个免疫检查点基因的表达及肿瘤浸润免疫细胞的丰度相关。

结论

这项关于SEMA7A的首次泛癌研究揭示了其在多种肿瘤类型中的预后和免疫学意义，表明其作为预测癌症不良预后和免疫细胞浸润的生物标志物具有潜在用途。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ec2a/11682669/785be92ff14a/IJGM-17-6443-g0011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ec2a/11682669/ef5978cb252b/IJGM-17-6443-g0001.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ec2a/11682669/7fa82ed4a8db/IJGM-17-6443-g0006.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ec2a/11682669/7f2d18bad806/IJGM-17-6443-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ec2a/11682669/0d9d83d26dae/IJGM-17-6443-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ec2a/11682669/0a505e300834/IJGM-17-6443-g0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ec2a/11682669/14b15a6bda03/IJGM-17-6443-g0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ec2a/11682669/7fa82ed4a8db/IJGM-17-6443-g0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ec2a/11682669/6b46ce2fcdf5/IJGM-17-6443-g0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ec2a/11682669/072767306221/IJGM-17-6443-g0008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ec2a/11682669/e235878e8b99/IJGM-17-6443-g0009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ec2a/11682669/f8b32db2af4a/IJGM-17-6443-g0010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ec2a/11682669/785be92ff14a/IJGM-17-6443-g0011.jpg

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