Zuo Yingying, Zhang Ru, Li Shuihong
Hengyang Medical School, University of South China, Hengyang, China.
The Seventh Affiliated Hospital of University of South China, Changsha, China.
Front Microbiol. 2024 Dec 13;15:1515291. doi: 10.3389/fmicb.2024.1515291. eCollection 2024.
is a major pathogen that causes upper and lower respiratory tract infections in children, adolescents, and elderly individuals and can lead to pneumonia, intrapulmonary and extrapulmonary complications, and respiratory sequelae. must adhere to respiratory epithelial cells of a host for infection. The P1 and P30 proteins, as two adhesin proteins of , have attracted extensive attention from many researchers. In this paper, we present the latest research progress on the P30 protein in terms of structure and mutation typing, physiological function, clinical serological diagnosis and vaccine development in a literature review. This study deepens our knowledge on the pathogenesis of and is useful for diagnosing and preventing infection.
是一种主要病原体，可导致儿童、青少年和老年人的上呼吸道和下呼吸道感染，并可引发肺炎、肺内和肺外并发症以及呼吸后遗症。 必须粘附于宿主的呼吸道上皮细胞才能进行感染。P1和P30蛋白作为 的两种粘附蛋白，已引起众多研究人员的广泛关注。在本文中，我们通过文献综述介绍了P30蛋白在结构和突变分型、生理功能、临床血清学诊断及疫苗研发方面的最新研究进展。本研究加深了我们对 发病机制的认识，有助于 感染的诊断和预防。
