纤连蛋白在恶性肿瘤中的可能作用。
Possible role of fibronectin in malignancy.
作者信息
Chen L B, Summerhayes I, Hsieh P, Gallimore P H
出版信息
J Supramol Struct. 1979;12(1):139-50. doi: 10.1002/jss.400120111.
PMID:397368
Abstract
Frozen sections of tumors induced by injecting virally transformed cells into animals were stained for fibronectin by immunofluorescence. Many tumor cell lines do not express fibronectin in tumors in situ even though some of them express fibronectin in culture. Cell shape and hormones appear to influence the expression of fibronectin in culture; however, it is unclear how fibronectin expression is regulated in vivo.
摘要
通过将病毒转化细胞注射到动物体内诱导产生的肿瘤冷冻切片，采用免疫荧光法对纤连蛋白进行染色。许多肿瘤细胞系在原位肿瘤中不表达纤连蛋白，尽管它们中的一些在培养中表达纤连蛋白。细胞形状和激素似乎影响培养中纤连蛋白的表达；然而，尚不清楚纤连蛋白的表达在体内是如何调控的。
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