Mensing H
Klin Wochenschr. 1985 Feb 15;63(4):145-51. doi: 10.1007/BF01732167.
Fibroblast are responsible for the synthesis of the structural proteins of the connective tissue. A further property of these cells, their migratory ability, could be analyzed in the last years. A special form of migration is chemotaxis, which can be quantitatively measured in a modified Boyden chamber in-vitro. Using this method chemoattractive substances could be characterized, which are able to stimulate fibroblasts and tumorcells to chemotactic migration. Furthermore it could be proved, that benign and transformed cell lines react in a different manner towards these chemoattractive substances. The in-vitro results allow some hypotheses about both fibroblast migration in wound healing or chronic inflammation, and the mechanisms of tumor cell evasion in the tumor surrounding tissue or the metastasizing process in other organs.
成纤维细胞负责合成结缔组织的结构蛋白。近年来，人们对这些细胞的另一特性，即其迁移能力进行了分析。一种特殊的迁移形式是趋化性，它可以在改良的博伊登室中进行体外定量测量。利用这种方法，可以鉴定出能够刺激成纤维细胞和肿瘤细胞进行趋化性迁移的化学吸引物质。此外，还证实了良性和转化细胞系对这些化学吸引物质的反应方式不同。体外实验结果为伤口愈合或慢性炎症中纤维母细胞的迁移，以及肿瘤细胞在肿瘤周围组织中的逃逸机制或在其他器官中的转移过程提供了一些假设。
