Sun Huaying, Wang Yumei, Yuan Dong, Duan Mengsi, Chen Zhuangfei, Fu Yu
Medical School, Kunming University of Science and Technology, Kunming, China.
School of Chinese Materia Medica and Key Laboratory of Yunnan Provincial Department of Education for Processing Research on Characteristic Prepared Drug in Pieces, Yunnan University of Chinese Medicine, Kunming, China.
Front Aging Neurosci. 2024 Dec 16;16:1492838. doi: 10.3389/fnagi.2024.1492838. eCollection 2024.
As a non drug and non invasive therapy, both transcranial alternating current stimulation (tACS) and transcranial direct current stimulation (tDCS) may modulate cortical rhythms and serve as potentially effective approaches to cognitive decline in Alzheimer's disease (AD). However, studies using animal models of AD are quite limited.
This study investigates the aftereffects of tACS and tDCS on brain EEG activity and associated exploratory behavior in normal aged and APP/PS1 transgenic mice (15 months old). Anodal tDCS and 10 Hz tACS (350 μA, 20 min) were applied once and EEGs were recorded from the hippocampus (Hip) and prefrontal cortex (PFC) during spontaneous home-cage state and open-field exploration.
A key finding was that tDCS induced significant alpha (8-12 Hz) EEG changes while tACS induced peak frequency changes in the group difference between normal aged and AD mice. However, both groups showed similar increases in theta (4-8 Hz) EEG activity during open-field exploration and increases in gamma (20-100 Hz) EEG activity in spontaneous state, suggesting that the ongoing physiological state may be related to some of the EEG changes.
This study provides insight into the short-term aftereffects of transcranial current stimulation in the aging and AD brain and is the first animal study to compare brain activity between tACS and tDCS treatments.
作为非药物和非侵入性治疗方法，经颅交流电刺激（tACS）和经颅直流电刺激（tDCS）均可调节皮层节律，并可能成为治疗阿尔茨海默病（AD）认知功能衰退的有效方法。然而，使用AD动物模型的研究相当有限。
本研究调查了tACS和tDCS对正常老龄和APP/PS1转基因小鼠（15个月大）脑电活动及相关探索行为的后续影响。单次施加阳极tDCS和10Hz的tACS（350μA，20分钟），并在自发笼内状态和旷场探索期间记录海马体（Hip）和前额叶皮层（PFC）的脑电图。
一个关键发现是，tDCS在正常老龄和AD小鼠的组间差异中诱导了显著的α（8-12Hz）脑电变化，而tACS诱导了峰值频率变化。然而，两组在旷场探索期间θ（4-8Hz）脑电活动均有类似增加，在自发状态下γ（20-100Hz）脑电活动也均有增加，这表明当前的生理状态可能与某些脑电变化有关。
本研究深入了解了经颅电流刺激在衰老和AD大脑中的短期后续影响，并且是第一项比较tACS和tDCS治疗后脑活动的动物研究。
