Zhang Zhuohao, Pan Meidie, Yang Xinyuan, Shang Luoran, Zhao Yuanjin
Shanghai Xuhui Central Hospital, Zhongshan-Xuhui Hospital, and the Shanghai Key Laboratory of Medical Epigenetics, the International Co-laboratory of Medical Epigenetics and Metabolism (Ministry of Science and Technology), Institutes of Biomedical Sciences, Fudan University, Shanghai, 200032, China.
Department of Ophthalmology, Eye & ENT Hospital of Fudan University, Fudan University, Shanghai, 200032, China.
Small Methods. 2025 May;9(5):e2401582. doi: 10.1002/smtd.202401582. Epub 2024 Dec 31.
Colored contact lenses have gained popularity among young individuals owing to their ability to alter the appearance of the wearer's eyes. However, conventional lenses containing chemical dyes are susceptible to detachment of the pigment layer, which can lead to corneal damage. In this research, a novel cellulose-based structural color contact lens (SCCL) is presented that enhances aesthetic appeal via a cholesteric liquid crystal (CLC) layer. Methacrylate-functionalized hydroxypropyl cellulose (HPCMA) molecules self-assemble into CLC and are cross-linked within the lens mold, resulting in the colored iris region of the contact lens. By employing multistep polymerization techniques, lenses with composite colors and intricate shapes are fabricated. Moreover, by incorporating bioderived antimicrobial peptides into the structurally colored region of the lens, SCCLs are achieved with good biocompatibility, controlled drug release, and broad-spectrum antibacterial activity. The results of in vivo experiments using an animal model indicate that the SCCLs perform well in the treatment of bacterial keratitis. It is believed that these drug-loaded structurally colored contact lenses will lead to various advancements in ocular medical devices and provide antibacterial protection against infectious keratitis in the future.
彩色隐形眼镜因其能够改变佩戴者眼睛外观而在年轻人中广受欢迎。然而，含有化学染料的传统镜片易出现色素层脱落，这可能导致角膜损伤。在本研究中，提出了一种新型的基于纤维素的结构彩色隐形眼镜（SCCL），其通过胆甾相液晶（CLC）层增强美学吸引力。甲基丙烯酸酯功能化的羟丙基纤维素（HPCMA）分子自组装成CLC并在镜片模具内交联，从而形成隐形眼镜的彩色虹膜区域。通过采用多步聚合技术，制造出具有复合颜色和复杂形状的镜片。此外，通过将生物衍生的抗菌肽纳入镜片的结构着色区域，实现了具有良好生物相容性、可控药物释放和广谱抗菌活性的SCCL。使用动物模型进行的体内实验结果表明，SCCL在治疗细菌性角膜炎方面表现良好。相信这些载药结构彩色隐形眼镜将在眼科医疗设备方面带来各种进步，并在未来为感染性角膜炎提供抗菌保护。
