Lifshitz F, Wapnir R A
J Pediatr. 1985 Mar;106(3):383-9. doi: 10.1016/s0022-3476(85)80661-2.
Eight solutions of potential efficacy for hydration orally, which differed in composition, osmolality, and pH, were tested in an in vivo perfusion system on rat jejunum to assess the rate of water and sodium absorption or secretion. Optimal results were obtained with a preparation of the type recommended by the World Health Organization, containing 60 mEq/L sodium and 111 mM glucose; there was a maximum influx of both water and sodium, which may be ideal for rehydration. It appeared that the critical factor was the molar relationship between glucose and sodium at a 2:1 ratio. Sodium absorption was inversely correlated with glucose concentration in the perfusates. Osmolality and pH may also have a role in the regulation of fluxes across the mucosa. Citrate at concentrations up to 30 mEq/L did not interfere with water absorption. The data presented may thus contribute to a better rationale for the use of orally administered hydration solutions and guidelines for the preparation of more effective ready-to-use solutions.
在大鼠空肠的体内灌注系统中测试了八种口服补水的潜在有效溶液，它们在成分、渗透压和pH值方面存在差异，以评估水和钠的吸收或分泌速率。使用世界卫生组织推荐的类型制剂可获得最佳结果，该制剂含有60 mEq/L的钠和111 mM的葡萄糖；水和钠的流入量最大，这可能是补液的理想选择。关键因素似乎是葡萄糖与钠的摩尔比为2:1。灌注液中钠的吸收与葡萄糖浓度呈负相关。渗透压和pH值也可能在调节跨粘膜通量中起作用。浓度高达30 mEq/L的柠檬酸盐不会干扰水的吸收。因此，所呈现的数据可能有助于更好地说明口服补液溶液的使用原理，并为制备更有效的即用型溶液提供指导。
