Das Abhishek, Thulaseedharan Devu K, Shah Parag K, Subramaniam Prema, Venkatapathy Narendran
Department of Pediatric Retina & Ocular Oncology, Aravind Eye Hospital & Postgraduate Institute of Ophthalmology, Avinashi Road, Coimbatore, 641 014, Tamil Nadu, India.
Graefes Arch Clin Exp Ophthalmol. 2024 Dec 30. doi: 10.1007/s00417-024-06728-y.
To describe the spectrum, demographic profile and distribution of intraocular oncology cases; both benign and malignant, in pediatric population in India.
It was a retrospective study done at a tertiary care hospital over a period of seven years (January 2015- December 2022) which included all the children aged 0-16 years, clinically diagnosed as intraocular tumors (benign or malignant) referred to our Ocular Oncology clinic. The data was retrieved from medical records department as well as electronic medical system (EMR) system. Age-wise distribution and demographic details were analyzed amongst these children.
A total of 310 (n = 445) patients were included. Mean age at presentation was 28.80 ± 28.58 months (median, 22 months; range, 0-176). Males were 168 (54.2%) and females were 142 (45.9%). 43.9% of the patients were in the age group between 2 and 3 years. 69.1% of the patients travelled around 100-500 km for treatment. Mean duration of symptoms was 4.7 ± 8.9 months, mean time interval between symptom and visit to our hospital was 4.8 ± 8.9 months and mean total follow-up period was 34 ± 30.7 months (median, 25 months; range, 0-105). Leukocoria (65.5%) was the most common presenting symptom amongst all the patients. Most common intraocular tumor amongst all the age group was retinoblastoma (88.4%). This was followed by combined hamartoma of retina and retinal pigment epithelium (CHRRPE) (3%, n = 11), astrocytic hamartoma (2.6%, n = 15), retinocytoma (1.6%, n = 5), choroidal hemangioma (1%, n = 3), simple hamartoma of retinal pigment epithelium (RPE) (1%, n = 3), Medulloepithelioma (1%, n = 3) and others (2%).
The most common malignant tumor was retinoblastoma and benign tumor was CHRRPE. Appropriate referral and early detection of these oncological diseases will play a crucial role in their prognosis and outcome.
描述印度儿科人群眼内肿瘤病例（包括良性和恶性）的种类、人口统计学特征及分布情况。
这是一项在一家三级医疗中心进行的回顾性研究，为期七年（2015年1月至2022年12月），纳入所有0至16岁临床诊断为眼内肿瘤（良性或恶性）并转诊至我们眼科肿瘤门诊的儿童。数据从病历科以及电子医疗系统（EMR）中获取。对这些儿童的年龄分布和人口统计学细节进行分析。
共纳入310例（n = 445）患者。就诊时的平均年龄为28.80±28.58个月（中位数为22个月；范围为0至176个月）。男性168例（54.2%），女性142例（45.9%）。43.9%的患者年龄在2至3岁之间。69.1%的患者前往距离约100至500公里的地方接受治疗。症状的平均持续时间为4.7±8.9个月，从出现症状到就诊于我院的平均时间间隔为4.8±8.9个月，平均总随访期为34±30.7个月（中位数为25个月；范围为0至105个月）。白瞳症（65.5%）是所有患者中最常见的就诊症状。所有年龄组中最常见的眼内肿瘤是视网膜母细胞瘤（88.4%）。其次是视网膜和视网膜色素上皮联合错构瘤（CHRRPE）（3%，n = 11）、星形细胞瘤（2.6%，n = 15）、视网膜细胞瘤（1.6%，n = 5）、脉络膜血管瘤（1%，n = 3）、视网膜色素上皮单纯错构瘤（RPE）（1%，n = 3）、髓上皮瘤（1%，n = 3）及其他（2%）。
最常见的恶性肿瘤是视网膜母细胞瘤，良性肿瘤是CHRRPE。对这些肿瘤性疾病进行适当转诊和早期检测对其预后和转归起着关键作用。
