近期感染艾滋病毒者中的艾滋病毒预防及错失的机会：一项系统评价方案

HIV prevention and missed opportunities among people with recently acquired HIV infection: Α protocol for a systematic review.

作者信息

Karakosta Argyro, Ruiz-Burga Elisa, Tariq Shema, Touloumi Giota, Jay Nicholls Emily, Pantazis Nikos, Jarrin Inma, Van der Valk Marc, Sabin Caroline, Mussini Cristina, Meyer Laurence, Volny Anne Alain, Carlander Christina, Grabar Sophie, Wittkop Linda, Spire Bruno, Gill Jonh, Porter Kholoud, Burns Fiona

机构信息

Institute for Global Health, University College London, London, United Kingdom.

Department of Hygiene, Epidemiology and Medical Statistics, Medical School, National and Kapodistrian University of Athens, Athens, Greece.

出版信息

PLoS One. 2024 Dec 31;19(12):e0295462. doi: 10.1371/journal.pone.0295462. eCollection 2024.

DOI:10.1371/journal.pone.0295462

PMID:39739779

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11687745/

Abstract

BACKGROUND

Individuals who have recently acquired HIV represent a unique population because the time frame since HIV acquisition is relatively short and identification of missed HIV prevention opportunities is, therefore, closer to real time and less subject to recall bias. Identifying prevention measures used and missed opportunities for using them, can help stop further HIV transmission.

OBJECTIVES

This systematic review aims to synthesise current global evidence on uptake of HIV prevention methods among people with recently acquired HIV from 2007, the year that the concept of ART as a prevention method was first introduced.

METHODS AND ANALYSIS

MEDLINE/PubMed, EMBASE, PsycINFO, Cochrane and Web of Science databases, will be searched for articles published January 2007-December 2023. Eligible studies will be those that reported on HIV prevention methods among people with recently acquired HIV. Quality assessment of the studies selected will be undertaken, and reporting of the systematic review will be informed by Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines.

RESULTS

The systematic review is expected to provide comprehensive insights into the uptake, use and adherence to HIV prevention methods among individuals with recently acquired HIV. Analysis anticipates identifying gaps in prevention coverage, missed opportunities for intervention, and variations in access to and use of prevention strategies. Sociodemographic, personal, and behavioural factors influencing prevention uptake and adherence will also be synthesised.

CONCLUSIONS

The findings will be of key relevance to researchers, healthcare providers including third sector organisations/ community groups and policymakers, as they will offer insight into better understanding of missed or failed HIV prevention efforts and will help ensure future efforts meet the needs of those in need of them.

摘要

背景

近期感染艾滋病毒的个体是一个独特的群体，因为自感染艾滋病毒以来的时间相对较短，因此识别错过的艾滋病毒预防机会更接近实时情况，且较少受到回忆偏差的影响。确定所采用的预防措施以及使用这些措施时错过的机会，有助于阻止艾滋病毒的进一步传播。

目的

本系统评价旨在综合当前全球范围内关于2007年以来近期感染艾滋病毒者采用艾滋病毒预防方法的证据，2007年首次引入了将抗逆转录病毒疗法作为一种预防方法的概念。

方法与分析

将检索MEDLINE/PubMed、EMBASE、PsycINFO、Cochrane和科学引文索引数据库，以查找2007年1月至2023年12月发表的文章。符合条件的研究将是那些报告近期感染艾滋病毒者的艾滋病毒预防方法的研究。将对所选研究进行质量评估，并根据系统评价和Meta分析的首选报告项目（PRISMA）指南进行系统评价的报告。