Karakosta Argyro, Ruiz-Burga Elisa, Tariq Shema, Touloumi Giota, Jay Nicholls Emily, Pantazis Nikos, Jarrin Inma, Van der Valk Marc, Sabin Caroline, Mussini Cristina, Meyer Laurence, Volny Anne Alain, Carlander Christina, Grabar Sophie, Wittkop Linda, Spire Bruno, Gill Jonh, Porter Kholoud, Burns Fiona
Institute for Global Health, University College London, London, United Kingdom.
Department of Hygiene, Epidemiology and Medical Statistics, Medical School, National and Kapodistrian University of Athens, Athens, Greece.
PLoS One. 2024 Dec 31;19(12):e0295462. doi: 10.1371/journal.pone.0295462. eCollection 2024.
Individuals who have recently acquired HIV represent a unique population because the time frame since HIV acquisition is relatively short and identification of missed HIV prevention opportunities is, therefore, closer to real time and less subject to recall bias. Identifying prevention measures used and missed opportunities for using them, can help stop further HIV transmission.
This systematic review aims to synthesise current global evidence on uptake of HIV prevention methods among people with recently acquired HIV from 2007, the year that the concept of ART as a prevention method was first introduced.
MEDLINE/PubMed, EMBASE, PsycINFO, Cochrane and Web of Science databases, will be searched for articles published January 2007-December 2023. Eligible studies will be those that reported on HIV prevention methods among people with recently acquired HIV. Quality assessment of the studies selected will be undertaken, and reporting of the systematic review will be informed by Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines.
The systematic review is expected to provide comprehensive insights into the uptake, use and adherence to HIV prevention methods among individuals with recently acquired HIV. Analysis anticipates identifying gaps in prevention coverage, missed opportunities for intervention, and variations in access to and use of prevention strategies. Sociodemographic, personal, and behavioural factors influencing prevention uptake and adherence will also be synthesised.
The findings will be of key relevance to researchers, healthcare providers including third sector organisations/ community groups and policymakers, as they will offer insight into better understanding of missed or failed HIV prevention efforts and will help ensure future efforts meet the needs of those in need of them.
近期感染艾滋病毒的个体是一个独特的群体，因为自感染艾滋病毒以来的时间相对较短，因此识别错过的艾滋病毒预防机会更接近实时情况，且较少受到回忆偏差的影响。确定所采用的预防措施以及使用这些措施时错过的机会，有助于阻止艾滋病毒的进一步传播。
本系统评价旨在综合当前全球范围内关于2007年以来近期感染艾滋病毒者采用艾滋病毒预防方法的证据，2007年首次引入了将抗逆转录病毒疗法作为一种预防方法的概念。
将检索MEDLINE/PubMed、EMBASE、PsycINFO、Cochrane和科学引文索引数据库，以查找2007年1月至2023年12月发表的文章。符合条件的研究将是那些报告近期感染艾滋病毒者的艾滋病毒预防方法的研究。将对所选研究进行质量评估，并根据系统评价和Meta分析的首选报告项目（PRISMA）指南进行系统评价的报告。
预计该系统评价将全面深入了解近期感染艾滋病毒者对艾滋病毒预防方法的采用、使用和依从情况。分析预计将确定预防覆盖方面的差距、错过的干预机会以及预防策略获取和使用方面的差异。还将综合影响预防采用和依从的社会人口学、个人和行为因素。
研究结果将对研究人员、包括第三部门组织/社区团体在内的医疗保健提供者以及政策制定者具有关键意义，因为它们将有助于更好地理解错过或失败的艾滋病毒预防努力，并有助于确保未来的努力满足有需要者的需求。
