Paes Lucia Regina do Nascimento Brahim, Oliveira Raquel de Vasconcellos Carvalhaes de, Magalhães Monica de Avelar F M, Pimentel Maria Inês Fernandes, Lyra Marcelo Rosandiski, Carvalho-Paes Luiz Eduardo, Costa Ananda Dutra da, Dias Cristina Maria Giodarno, Brahim Anísia Darc do Nascimento, Carvalho Bruno Moreira de, Duarte Claudia Cristina Jardim, Marzochi Mauro Celio de Almeida, Soares Ester Cleisla Dos Anjos, Schubach Armando de Oliveira, Valete-Rosalino Cláudia Maria
Evandro Chagas National Institute of Infectious Disease, Oswaldo Cruz Foundation, Rio de Janeiro, RJ, Brazil.
Institute of Scientific and Technological Communication and Information, Oswaldo Cruz Foundation, Rio de Janeiro, RJ, Brazil.
PLoS One. 2024 Dec 31;19(12):e0308298. doi: 10.1371/journal.pone.0308298. eCollection 2024.
To compare the spatio-temporal distribution of cutaneous leishmaniasis (CL) cases with mucosal leishmaniasis (ML) cases in the state of Rio de Janeiro (RJ) between 2001 and 2011.
The incidence rates (IR) of CL and ML were calculated for the cases notified between 2001-2011 in the Information System of Notifiable Diseases for Rio de Janeiro (RJ, and for the municipalities of Rio de Janeiro and Angra dos Reis, with georeferencing and construction of thematic maps. A negative binomial regression model was used to assess the temporal dependency between CL and ML.
Higher IR of CL and ML were observed up to 2006. The cases of CL and ML increased annually concomitantly in the state of RJ and in Angra dos Reis, even when they were controlled by the CL rates of the previous year. The municipality of Rio de Janeiro presented smaller annual CL IR after the occurrence of high ML IR in the two previous years.
The temporal association observed between CL and ML suggests that: either the mucosal lesions were already incipient from the beginning of CL manifestation, or the Leishmania species circulating in RJ is able to produce early mucosal lesions.
比较2001年至2011年里约热内卢州（RJ）皮肤利什曼病（CL）病例与黏膜利什曼病（ML）病例的时空分布。
计算2001 - 2011年里约热内卢法定传染病信息系统（RJ以及里约热内卢市和安格拉杜斯雷斯市）中报告的CL和ML病例的发病率（IR），进行地理定位并绘制专题地图。采用负二项回归模型评估CL和ML之间的时间依赖性。
到2006年观察到CL和ML的发病率较高。即使受上一年CL发病率控制，RJ州和安格拉杜斯雷斯市的CL和ML病例仍逐年增加。在前两年出现高ML发病率后，里约热内卢市的年度CL发病率较低。
CL和ML之间观察到的时间关联表明：要么黏膜病变在CL表现开始时就已初期存在，要么在RJ传播的利什曼原虫物种能够产生早期黏膜病变。
